摘要
目的比较波塞冬标准分组各组患者的临床特征和累积活产率。方法回顾性队列研究方法分析西北妇女儿童医院生殖中心在2014年1月1日至2018年1月31日期间接受体外受精-胚胎移植(IVF-ET)的低预后人群资料,随访时间至少1年。经严格排除标准后,共4120个新鲜完整周期纳入分析。这些患者按波塞冬标准分为4组:A组(年龄<35岁,窦卵泡数≥5枚,前次标准刺激获卵数≤9枚)共1092例,B组(年龄≥35岁,窦卵泡数≥5枚,前次标准刺激获卵数≤9)共480例,C组(年龄<35岁,窦卵泡数<5枚)共1132例,D组(年龄≥35岁,窦卵泡数<5枚)共1416例。比较各组患者基本临床资料、胚胎发育及累积活产率等。结果卵子输出率由高到低依次为C组(149.47%)、D组(112.06%)、B组(85.39%)、A组(81.81%),组间比较差异均有统计学意义(P均=0.0001)。无可移植胚胎率由高到低依次为D组(19.49%)、C组(15.37%)、B组(11.88%)、A组(10.90%),组间比较差异均有统计学意义(P均=0.0001)。累积活产率由高到低依次为A组(48.81%)、C组(35.07%)、B组(26.46%)及D组(14.55%),组间比较差异均有统计学意义(P均=0.0001)。结论波塞冬标准分组方法可以预测患者的累积活产率。年轻卵巢储备好的人群最高,年轻卵巢储备差的人群次之,高龄卵巢储备好的人群第三,高龄卵巢储备差的人群最低。
Objective To investigate the characteristics and outcomes of low prognosis patients based on POSEIDON criteria undergoing in vitro fertilization and embryo transfer(IVF-ET)treatment.Methods A retrospective cohort study was conducted to analyze the data of low prognosis patients undergoing IVF-ET in Reproductive Medicine Centre,the Northwest Women’s&Children’s Hospital between January 1,2014 to January 31,2018.The follow-up lasted at least one year.After strict exclusion criteria,4120 complete fresh cycles were included in the analysis.According to POSEIDON criteria,there were 1092 cases in group A[age<35 years,antral follicle count(AFC)≥5,number of oocytes retrieved in previous standard stimulation≤9],480 cases in group B(age≥35 years,AFC≥5,number of oocytes retrieved in previous standard stimulation≤9),1132 cases in group C(age<35 years,AFC<5),and 1416 cases in group D(age≥35 years,AFC<5).The baseline characteristics,embryonic development and cumulative live birth rates were compared among the groups.Results The oocytes output rate ranked from high to low in order of group C(149.47%),group D(112.06%),group B(85.39%)and group A(81.81%)with significantly differences(all P=0.0001).The non-usable embryo transplant rate ranked from high to low in order of group D(19.49%),group C(15.37%),group B(11.88%)and group A(10.90%)with significant differences(all P=0.0001).The cumulative live birth rate ranked from high to low in order of group A(48.81%),group C(35.07%),group B(26.46%)and group D(14.55%)with significant differences(all P=0.0001).Conclusion POSEIDON criteria grouping method can predict the cumulative live birth rate of patients.The cumulative live birth rate was the highest in the young women with good ovarian reserve,followed by the young women with diminished ovarian reserve,then the advanced age women with good ovarian reserve,and the lowest in the advanced age women with diminished ovarian reserve.
作者
黄愈
施文浩
师娟子
Huang Yu;Shi Wenhao;Shi Juanzi(Xi’an Medical University,Xi’an 710003,China;Reproductive Medicine Centre,the Northwest Women’s&Children’s Hospital Affiliated of Xi'an Jiaotong University,Xi’an 710003,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2020年第5期361-366,共6页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金(81771657)
陕西省科技厅一般项目-社会发展领域(2018SF-260)。
关键词
卵巢低反应
受精
体外
胚胎移植
累积活产率
低预后
波塞冬标准
Poor ovarian response
Fertilization in vitro
Embryo transfer
Cumulative live birth rate
Low prognosis
POSEIDON criteria
