摘要
肺动脉高压(pulmonary hypertension,PH)是指肺动脉压力异常升高的一种病理生理状态,引起右心室肥大,导致右心衰竭,甚至死亡。肺动脉高压的发生、发展过程至今尚未阐明,具有较高的死亡率,预后较差,且目前缺乏有效的治疗药物。PH动物模型包括野百合碱诱导模型、慢性低氧性模型、栓塞性模型、手术分流模型、遗传修饰模型、混合因素诱导模型等。该文对各种肺动脉高压动物模型进行总结,分析其优缺点以及各模型对临床PH的模拟性,为研究者在寻找PH的病理生理机制、研发治疗药物的过程中选择合适的动物模型提供参考。
Pulmonary hypertension(PH)refers to a pathophysiological state in which pulmonary artery pressure is abnormally elevated,causing right ventricular hypertrophy,right heart failure and even death.The occurrence and development of PH has not been elucidated so far.It has a high mortality rate,a poor prognosis,and currently lacks effective therapeutic drugs.Animal models of PH include monocrotaline model,chronic hypoxia model,embolic model,surgical shunt model,genetic modification model,multiple-pathological-insult model and so on.This article summarizes the animal models of PH,analyzes its advantages,disadvantages and the simulation of clinical PH of each model,hoping to provide references for the researchers to choose appropriate models for studying specific pathogenic mechanism and developing therapeutic drugs.
作者
孙姝婵
方莲花
杜冠华
SUN Shu-chan;FANG Lian-hua;DU Guan-hua(Beijing Key Lab of Drug Targets Identification and Drug Screening,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2020年第8期1037-1040,共4页
Chinese Pharmacological Bulletin
基金
中国医学科学院医学与健康科技创新工程项目(No 2017-I2M-1-010,2016-I2M-3-007)
国家自然科学基金资助项目(No 81773935)
国家科技重大专项(No 2018ZX09711001-001-014,2017ZX09101001)。
关键词
肺动脉高压
动物模型
低氧
栓塞性
模拟性
药物研发
研究进展
pulmonary hypertension
animal models
hypoxia
embolic
simulation
drug development
research progress
