摘要
目的:探讨急性脑梗死(ACI)患者血清趋化素(Chemerin)水平变化,分析其与脑梗死面积、神经功能缺损的相关性。方法:纳入临床确诊的ACI患者80例作为观察组,根据美国国立卫生研究院卒中量表(NIHSS)评分分成轻型组(NIHSS<6分)、中型组(6分≤NIHSS≤13分)、重型组(NIHSS>13分),根据梗死面积分成小面积梗死组(1.5cm≤直径<3cm)、中面积梗死组(3cm≤直径<5cm)、大面积梗死组(直径≥5cm),同时纳入健康体检者80例作为对照组。酶联免疫吸附实验检测血清Chemerin水平,Pearson法分析Chemerin水平与NIHSS评分、脑梗死面积的相关性。结果:(1)与对照组比较,观察组患者血清Chemerin水平明显升高,差异有统计学意义(P均<0.01)。(2)中型组、重型组血清Chemerin均较轻型组明显升高,差异有统计学意义(P均<0.01)。(3)与小面积梗死组比较,中面积梗死组、大面积梗死组血清Chemerin水平均明显升高,差异有统计学意义(P均<0.01)。(4)Pearson相关分析显示:血清Chemerin水平与NIHSS评分、脑梗死面积呈明显正相关(r=0.654、0.068,P均<0.05)。结论:ACI患者血清Chemerin明显升高,其水平与ACI病情严重程度呈正相关。
Objective:To investigate the variation of serum chemerin in the patients with acute cerebral infarction(ACI),and to explore the relationships of serum chemerin with neurological deficit and cerebral infarction area.Methods:80 patients with ACI were selected as the observation group.The all patients with ACI were divided into three groups:the mild group(NIHSS score<6),the moderate group(6≤NIHSS score≤13)and the severe group(NIHSS score>13)according to the National Institutes of Health Stroke Scale(NIHSS)score and another three groups:small area infarct group(1.5cm≤maximum diameter<3cm),middle area infarct group(3cm≤maximum diameter<5cm)and large area infarct group(maximum diameter≥5cm).Another 80 people with healthy subjects were selected as the control group.Enzyme linked immunosorbent assay was used to detect the levels of serum chemerin.Pearson method was used to analyze the correlation between serum chemerin level with NIHSS score and cerebral infarction area.Results:(1)Compared with the control group,the levels of serum chemerin in the observation group was significantly increased(P<0.01).(2)The levels of serum chemerin in the moderate group and the severe group were higher than that of the mild group(all P<0.01).(3)Compared with the small area infarct group,both the levels of serum chemerin in the middle area infarct group and the large area infarct group were significantly increased(all P<0.01).(4)Correlation analysis revealed that the levels of serum chemerin in the patients with acute cerebral infarction were positively correlated with NIHSS score and cerebral infarction area(r=0.654,0.608,both P<0.01).Conclusion:The levels of chemerin in the patients with acute cerebral infarction were significantly increased,and it was closely positive correlated with the severity of acute cerebral infarction.
作者
许玉兰
XU Yulan(Department of Neurology,the Second Hospital of Sanming,Yongan City,Fujian Province 366000)
出处
《医学理论与实践》
2020年第15期2423-2425,共3页
The Journal of Medical Theory and Practice
关键词
急性脑梗死
趋化素
神经功能缺损
梗死面积
相关性
Acute cerebral infarction
Chemerin
Neurological deficit
Infarction area
Correlation
