摘要
表观遗传学包括DNA、RNA和蛋白质的化学修饰,其中RNA甲基化研究已成为表观遗传领域的研究热点。在RNA甲基化修饰中,6-甲基腺嘌呤(N6-methyladenosine,m6A)是最常见、最丰富的真核生物信使RNA(messenger RNA,mRNA)转录后修饰,主要由m6A甲基转移酶催化,m6A去甲基酶去除,并由m6A结合蛋白识别。这个动态可逆的生物学过程,可以对mRNA产生不同的生物学作用,包括mRNA剪切、出核、降解、影响mRNA稳定性和翻译效率等。多项研究表明m6A相关蛋白参与了不同类型肿瘤的发生、发展,以及肿瘤耐药发展的过程。本文就m6A RNA甲基化在肿瘤耐药中的作用做一综述。
Epigenetics include chemical modifications of DNA,RNA,and proteins.The study of RNA methylation has become a hot topic in the field of epigenetics.N6-methyladenosine(m6A)is the most common and abundant eukaryotic post-transcriptional modi fi cation in the methylation of mRNA,which is mainly installed,recognized,and erased post-transcriptionally through m6A methyltransferases(writer),demethylases(eraser),and m6A-specific binding proteins(readers).This dynamic reversible biological process have different biological effects on mRNA,including mRNA shearing,nucleating,degrading,affecting mRNA stability and transl ation efficiency.Many studies have shown that m6A related proteins are involved in the development of different types of cancer,as well as the development of drug resistance in cancer therapy.This article reviews the role of m6A RNA methylation in cancer resistance.
作者
陈琛
李永文
潘红丽
刘红雨
陈军
Chen Chen;Li Yongwen;Pan Hongli;Liu Hongyu;Chen Jun(Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment,Tianjin Lung Cancer Institute,Tianjin 300052,China;Department of Lung Cancer Surgery,Tianjin Medical University General Hospital,Tianjin 300052,China)
出处
《中国医学前沿杂志（电子版）》
2020年第7期1-6,I0001,共7页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
国家自然科学基金项目(81773207)
天津市科技支撑计划重点项目(19YFZCSY00040)
天津市拔尖创新团队计划(TJTZJHGCCCXCYTD-2-6)。
