摘要
目的对比分析输尿管软镜钬激光碎石术前口服坦索罗辛与双氯芬酸钠的临床作用。方法选取2017年1月至2019年1月郑州人民医院泌尿外科收治的90例拟行输尿管软镜钬激光碎石术治疗的输尿管上段结石患者作为研究对象,并按照入院顺序单双号分为观察组(45例)和对照组(45例),观察组患者于输尿管软镜钬激光碎石术前口服盐酸坦索罗辛缓释胶囊,对照组患者于输尿管软镜钬激光碎石术前口服双氯芬酸钠缓释胶囊,对比两组患者手术时间、术中出血量、排石成功率以及术中输尿管黏膜损伤、穿孔、出血等并发症发生情况结果观察组患者手术时间及术中出血量与对照组均无明显差异(t=0.725、0.621,P=0.470、0.536),但排石成功率明显高于对照组(χ^2=5.294,P=0.021),并发症发生率明显低于对照组(χ^2=6.154,P=0.013)。结论与双氯芬酸钠相比,输尿管软镜钬激光碎石术前应用坦索罗辛能有效预防术中输尿管黏膜损伤等并发症的发生,提高排石成功率,且药物不良反应轻微,对手术无影响,安全性较高,值得临床推广应用。
Objective To compare and analyze the clinical effect of oral administration of tamsulosin and diclofenac sodium in flexible ureteroscopic lithotripsy.Methods 90 patients suffering from upper ureteral stone treated with ureteroscopic holmium laser lithotripsy,admitted to Department of Urology,Zhengzhou People’s Hospital from January 2017 to January 2019,were selected as research subjects and divided,according to the odevity of admission number,into an observation group(45 cases)and a control group(45 cases).Patients in the observation group took tamsulosin hydrochloride sustained-release capsules orally before ureteroscopic holmium laser lithotripsy,while patients in the control group took diclofenac sodium sustained-release capsules orally before ureteroscopic holmium laser lithotripsy.The surgery time,blood loss during surgery,stone clearance rate and the incidence of such complications as the injury,perforation and bleeding of ureteral mucosa were compared between the two groups.Results No significant difference was observed in surgery time and blood loss during surgery between the two groups(t=0.725,0.621,P=0.470,0.536),the stone clearance rate in the observation group was significantly higher than that in the control group(χ^2=5.294,P=0.021)and the incidence of complications in the observation group was significantly lower than that in the control group(χ^2=6.154,P=0.013).Conclusion Compared with the application of diclofenac sodium,the application of tamsulosin before ureteroscopic holmium laser lithotripsy can prevent the occurrence of complications such as the injury of ureteral mucosa and improve stone clearance rate.It has mild adverse reactions and is very safe to be used in surgery.Therefore,it derserves to be promoted in clinical practice.
作者
李慎谟
Li Shenmo(Department of Urology,Zhengzhou People’s Hospital,Zhengzhou City,Henan 450014,China)
出处
《中国烧伤创疡杂志》
2020年第4期279-282,共4页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
坦索罗辛
双氯芬酸钠
输尿管软镜
钬激光碎石
输尿管结石
Tamsulosin
Diclofenac sodium
Flexible ureteroscope
Holmium laser lithotripsy
Ureteral stone
