摘要
目的:探讨食管鳞癌患者远处转移部位与预后的相关性及生存分析。方法:从SEER数据库中提取2010年至2015年共439例食管鳞癌伴远处转移患者的临床资料,回顾性分析比较食管鳞癌远处转移部位与预后的相关性,通过χ~2检验比较两组变量的差异,采用Kaplan-Meier法绘制生存曲线,Log-rank检验进行单因素分析,COX回归进行多因素分析。结果:肺转移、骨+肺转移、肝+肺转移患者预后较好;骨转移、脑转移、骨+脑转移、骨+脑+肝+肺转移患者预后较差。单因素分析显示:年龄、原发灶部位、T分期、手术情况、多器官转移情况与食管鳞癌远处转移患者的预后有关(P<0.05);多因素分析显示:年龄、手术情况与多器官转移情况是影响食管鳞癌远处转移患者总生存时间(OS)的独立危险因素。结论:食管鳞癌伴远处转移的患者整体预后较差,但年龄在60~69岁区间、接受手术治疗与较好的预后相关。仅单器官转移的食管鳞癌患者中,骨转移、脑转移患者预后较差;合并多器官转移的患者中,骨+脑转移、骨+脑+肝+肺转移患者预后较差。
Objective:To investigate the prognostic factors and survival analysis of patients with esophageal squamous cell carcinoma with distant metastasis.Methods:The clinical data of 439 patients with distant metastasis of esophageal squamous cell carcinoma from 2010 to 2015 were extracted from SEER database.The effects of distant metastasis on the prognosis of esophageal squamous cell carcinoma were retrospectively analyzed and compared.The differences between the two groups of variables were compared byχ2 test.The survival curve was drawn by Kaplan-Meier method.Log-rank test was used for univariate analysis and COX regression for multivariate analysis.Results:The prognosis of lung metastasis,bone+lung metastasis and liver+lung metastasis was better,while that of bone metastasis,brain metastasis,bone+brain metastasis and bone+brain+liver+lung metastasis was poor.Univariate analysis showed that age,primary location,T stage,operation and multiple organ metastasis were related to the prognosis of patients with distant metastasis of esophageal squamous cell carcinoma(P<0.05).Multivariate analysis showed that age,operation and multiple organ metastasis were independent factors affecting OS in patients with distant metastasis of esophageal squamous cell carcinoma.Conclusion:The overall prognosis of patients with esophageal squamous cell carcinoma with distant metastasis is poor,but the age range of 60~69 years old and surgical treatment are related to a better prognosis.In patients with esophageal squamous cell carcinoma with only single organ metastasis,the prognosis of bone metastasis and brain metastasis is poor.In patients with multiple organ metastasis,the prognosis of bone+brain metastasis and bone+brain+liver+lung metastasis is poor.
作者
周莹
王裴
路宁
王艺璇
张晓庆
李敏娜
崔曼莉
张明鑫
Zhou Ying;Wang Pei;Lu Ning;Wang Yixuan;Zhang Xiaoqing;Li Minna;Cui Manli;Zhang Mingxin(The Second Clinical Medical College,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;The First Affiliated Hospital of Xi'an Medical University,Shaanxi Xi'an 710077,China)
出处
《现代肿瘤医学》
CAS
2020年第16期2804-2811,共8页
Journal of Modern Oncology
基金
陕西省教育厅专项项目(编号:19JK0765)
西安市科技局计划项目[编号:2019114713YX002SF035(1),2019114713YX002SF035(6)]。
关键词
食管鳞癌
远处转移
预后
生存分析
SEER数据库
esophageal squamous cell carcinoma
distant metastasis
prognosis
survival analysis
SEER database
