摘要
目的研究高血压脑出血患者血清神经生长因子(NGF)和白介素-6(IL-6)水平变化与临床预后的关系。方法选取62例高血压脑出血患者作为研究组,根据患者入院时格拉斯哥昏迷指数(GCS)评分分为轻度组(GCS评分13~14分,12例)、中度组(GCS评分9~12分,31例)、重度组(GCS评分3~8分,19例)。另选取40例同期住院非神经系统损伤患者作为对照组。所有患者均给予综合性治疗,并采用酶联免疫吸附测定(ELISA)检测血清NGF及IL-6水平。观察比较四组患者不同时间NGF及IL-6水平;比较轻度组、中度组和重度组的GCS和美国国立卫生研究院卒中量表(NIHSS)评分。结果发病第2天、第7天、第21天、第6周及3个月,重度组和中度组血清NGF及IL-6水平均高于轻度组,差异有统计学意义(P<0.05);轻度组、中度组及重度组血清NGF及IL-6水平均高于对照组,差异有统计学意义(P<0.05)。发病第2天、第7天、第21天、第6周及3个月,中度组GCS评分分别为(10.51±1.13)、(10.96±1.05)、(11.65±0.85)、(12.69±0.61)、(13.56±0.58)分,重度组GCS评分分别为(6.34±1.11)、(7.65±1.05)、(7.96±1.01)、(9.96±0.69)、(10.65±0.36)分,均低于轻度组的(12.65±1.05)、(13.65±0.58)、(13.96±0.05)、(14.85±0.03)、(14.96±0.01),差异有统计学意义(P<0.05)。发病第2天、第7天、第21天、第6周及3个月,中度组和重度组NIHSS评分均高于轻度组,差异有统计学意义(P<0.05)。结论对高血压脑出血患者血清NGF和IL-6水平实施观察,其水平越高患者预后越差,值得应用。
Objective To study the correlation between changes of serum nerve growth factor(NGF),interleukin-6(IL-6)and clinical prognosis in patients with hypertensive intracerebral hemorrhage.Methods There were 62 patients with hypertensive intracerebral hemorrhage selected as research group,and they were divided into mild group[Glasgow coma scale(GCS)sore 13-14 points,12 cases],moderate group(GCS score 9-12 points,31 cases)and severe group(GCS score 3-8 points,19 cases)by GCS score at admission.Another 40 hospitalized patients without neurological injury at the same time were selected as the control group.All patients received comprehensive therapy,and the levels of serum NGF and IL-6 were detected by enayme liked immunosorbent assay(ELISA).The levels of NGF and IL-6 at different time points of the four groups were observed and compared.GCS and National Institutes of Health stroke scale(NIHSS)scores of mild group,moderate group and severe group were compared.Results On the 2 nd day,7 th day,21 st day,6 th month and 3 rd month of onset,the levels of serum NGF and IL-6 of severe group and moderate group were higher than those of mild group,and the difference was statistically significant(P<0.05).The levels of serum NGF and IL-6 of mild group,severe group and moderate group were higher than those of the control group,and the difference was statistically significant(P<0.05).On the 2 nd day,7 th day,21 st day,6 th month and 3 rd month of onset,GCS score of moderate group were(10.51±1.13),(10.96±1.05),(11.65±0.85),(12.69±0.61)and(13.56±0.58)points,and those were(6.34±1.11),(7.65±1.05),(7.96±1.01),(9.96±0.69)and(10.65±0.36)points of severe group,which were all lower than those of mild group(12.65±1.05),(13.65±0.58),(13.96±0.05),(14.85±0.03)and(14.96±0.01)points,and the difference was statistically significant(P<0.05).On the 2 nd day,7 th day,21 st day,6 th month and 3 rd month of onset,NIHSS score of moderate group and severe group were higher than those of mild group,and the difference was statistically significant(P<0.05).Conclusion Serum NGF and IL-6 levels can be observed to assess the conditions of patients with hypertensive intracerebral hemorrhage.The higher the level,the worse the prognosis.It is worthy of application.
作者
何贵文
黎宁菲
黄剑
蔡学坚
徐镇涛
黎嘉俊
冯文聪
HE Gui-wen;LI Ning-fei;HUANG Jian(Department of Neurosurgery,Dongguan Integrated Traditional and Western Medicine Hospital,Dongguan 523820,China)
出处
《中国实用医药》
2020年第16期1-3,共3页
China Practical Medicine
基金
2019年东莞市社会科技发展(一般)项目(项目编号:201950715042652)项目名称:高血压脑出血患者血清NGF和IL-6水平变化与临床预后的关系。
关键词
高血压脑出血
血清神经生长因子
白介素-6
预后
Hypertensive intracerebral hemorrhage
Serum nerve growth factor
Interleukin-6
Prognosis
