摘要
癌症是严重威胁人类生活和健康的重大疾病。由于胃部解剖学位置特点及其具有的与其他器官完全不同的酸性环境,重金属污染物在诱导胃癌发生中的作用必须得到重视。大量流行病学研究显示,土壤、灌溉水、饮用水和食品中重金属含量与胃癌发病率之间存在正相关性。重金属元素通过破坏胃粘膜屏蔽、导致胃上皮及内皮组织产生过度氧化应激反应、干扰细胞信号通道和基因表达、与生物大分子相结合导致蛋白质和DNA分子的损伤、破坏DNA损伤的修复作用、以及影响基因的表观遗传学作用等机理使细胞发生恶性转化。机理分析发现,重金属可以和幽门螺旋杆菌协同作用,提高胃癌的发病率。因此,冶金、矿业、材料、化工和食品等产业,农田土壤和水质修复工作等在涉及重金属污染物的问题时应该有更严格和全面的措施。
Cancer is a kind of serious diseases threatening human life and health.Due to the anatomic location of stomach and its acid environment which is completely different from other organs,the role of heavy metal pollutants in the induction of gastric cancer must be taken seriously.A large number of epidemiological studies have shown that there is a positive correlation between heavy metal content in soil,irrigation water,drinking water and food with the incidence rate of gastric cancer.Heavy metals cause malignant transformation of cells by destroying the barrier of gastric mucosa,causing excessive oxidative stress reaction in gastric epithelium and endothelium,interfering with cell signal channels and gene expression,combining with biological macromolecules,leading to damage of protein and DNA molecules,damaging the repair effect of DNA damage,and affecting the epigenetic effect of genes.The heavy metals can synergy with Helicobacter pylori and increase the incidence rate of gastric cancer.Therefore,in metallurgy,mining,materials,chemical industry,food and other industries,farmland soil and water quality remediation work should have more strict and comprehensive measures when it comes to heavy metal pollutants.
作者
任婷
赵丽娇
钟儒刚
REN Ting;ZHAO Li-jiao;ZHONG Ru-gang(Beijing Key Laboratory of Environmental&Viral Oncology,College of Life Science and Bioengineering,Beijing University of Technology,Beijing 100124,China)
出处
《化学试剂》
CAS
北大核心
2020年第7期797-802,共6页
Chemical Reagents
基金
国家自然科学基金资助项目(21778011)
北京市长城学者支持计划项目(CIT&TCD20180308)
北京市百千万人才工程培养项目(2019A16)
北京市教委重点实验室项目(PXM2015-014204-500175)。
关键词
重金属
胃癌
致癌机理
协同作用
癌症防治
heavy metals
gastric cancer
carcinogenic mechanism
synergism
cancer prevention
