摘要
终末期肝病患者由于肝脏内环境改变、免疫防御能力低下、肠壁屏障功能减退等原因增加了被感染的机会。常见感染包括肺炎、自发性细菌性腹膜炎、胆道及尿路感染、皮肤软组织感染及自发性菌血症,严重者可引起脓毒症和感染性休克。感染可加剧肝脏及相关脏器损伤的进展,严重者危及生命。早期发现与诊断、采用有效抗菌药物及支持治疗是挽救患者生命的的关键。
Patients with end-stage liver disease are more likely to be infected due to the changes in the liver’s internal environment,low immune defense capabilities and reduced gut barrier function.Common infections include pneumonia,spontaneous bacterial peritonitis,biliary and urinary tract infections,skin and soft tissue infections,and spontaneous bacteremia,which in severe cases can lead to sepsis and septic shock.Importantly,infections can aggravate and progress to the liver and damage correlated organs,and thus can be life-threatening in severe cases.Therefore,early detection and diagnosis,as well as the use of effective antibacterial agents,and supportive treatment are keys to saving patients'lives.
作者
南月敏
刘领弟
Nan Yuemin;Liu Lingdi(Key Laboratory of Study on Mechanism of Hepatic Fibrosis in Chronic Liver Disease in Hebei Province,Department of Traditional and Western Medical Hepatology,Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2020年第7期545-547,共3页
Chinese Journal of Hepatology
关键词
终末期肝病
感染
多重耐药菌
抗菌治疗
支持治疗
End stage of liver disease
Infection
Multi-drug resistant bacteria
Antibiotic therapy
Supportive treatment
