摘要
非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)是一类慢性的、与肥胖相关的肝脏疾病,目前已成为儿童中最常见的肝脏疾病之一。NAFLD同样被视为儿童代谢综合征的肝脏表现,并且与儿童肥胖、胰岛素抵抗、脂代谢异常甚至心血管疾病密切相关,因此,应对儿童NAFLD的预防及诊治给予足够重视。有研究显示,在NAFLD的发病过程中果糖代谢异常发挥了重要作用。该文对生理及病理状态下果糖在肝脏中代谢的异同进行比较和深入的总结分析,以便更好地理解NAFLD的发病机制。同时试图阐明NAFLD相关的临床研究和基础研究需要克服的问题及未来的研究方向,以利于深入了解NAFLD的发病机制,做到早期诊断NAFLD的同时发展新的干预手段和治疗靶点,努力降低儿童NAFLD的发病率并改善其预后,从而提高更多肥胖及NAFLD患儿的生活质量。
Nonalcoholic fatty liver disease(NAFLD)refers to a chronic,obesity-related liver disease,which has become one of the most common liver diseases in children.NAFLD is also regarded as the liver symptom of metabolic syndrome in children,which is closely related with obesity,insulin resistance,abnormal lipid metabolism and even cardiovascular-related disease in children.Therefore,it is noteworthy to provide more concerns and efficiency strategies regarding prevention and treatment of NAFLD in children.Previous studies have shown that abnormal fructose metabolism could play an essential role in the physiopathological process of NAFLD.Here in,this study aims to perform the comparation of the similarities and differences regarding fructose metabolism in liver under physiological and pathological conditions,in addition,to clarify the problems and challenges that need to be overcome in clinical studies and bench work related to NAFLD.
作者
夏婧
高艳艳
刘洋
马亚楠(综述)
闻德亮(审校)
Xia Jing;Gao Yanyan;Liu Yang;Ma Yanan;Wen Deliang(Department of Pediatric Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China;Institute of Health Sciences,China Medical University,Shenyang 110122,China)
出处
《国际儿科学杂志》
2020年第6期420-424,共5页
International Journal of Pediatrics
基金
美国中华医学基金(CMB-OC-18-291)
2017年辽宁省重点研发计划指导计划资源平台建设项目(2017225004)。
关键词
儿童
果糖
非酒精性脂肪肝
代谢
Children
Fructose
Nonalcoholic fatty liver disease
Metabolism
