摘要
生长因子主要包括血管内皮生长因子(VEGF)、转化生长因子β(TGF-β)、血小板源性生长因子(PDGF)、结缔组织生长因子(CTGF)、成纤维细胞生长因子(FGF)、肝细胞生长因子(HGF)等,早期探讨上述生长因子在肺动脉高压(PAH)发展中的作用机制,明确其在PAH治疗中的应用价值,以期为临床鉴别诊断、对症治疗提供新方向.
Growth factors include vascular endothelial growth factor(VEGF),transforming growth factor beta(TGF-β),platelet-derived growth factor(PDGF),connective tissue growth factor(CTGF),fibroblast growth factor(FGF),hepatocyte growth factor(HGF). Early exploration of the mechanism of the above growth factors in the development of pulmonary hypertension(PAH)defines the application value in the treatment of PAH and provides a new direction for clinical differential diagnosis and symptomatic treatment.
作者
李凯泽
刘广雁
陈建英
LI Kaize;LIU Guangyan;CHEN Jianying(Division 3,Department of Cardiovascular Medicine,Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong,China,524000)
出处
《分子诊断与治疗杂志》
2020年第7期978-981,共4页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金面上项目(81370242)
广东医科大学附属医院干细胞临床前研究项目(2018PSSC006)。
关键词
生长因子
肺动脉高压
发病机制
Growth factor
Pulmonary hypertension
Pathogenesis
