摘要
利用氮杂环卡宾(NHC)独特的Br?nsted碱性催化二烯酮与氰基乙酸酯的双Michael加成反应.在10mol%NHC催化下,二乙烯酮可以与氰基乙酸酯反应,以60%~89%的产率和5∶1~>20∶1的dr值得到多取代环己酮.在相同反应条件下,邻苯二烯酮与氰基乙酸酯和丙二腈等反应,以77%~98%的产率和>20∶1的dr值得到多取代茚产物.
The unique Brønsted basic character of N-heterocyclic carbenes(NHCs)has been used to catalyze the double Michael addition between dienones and cyanoacetates.In the presence of 10 mol%NHC,divinyl ketones reacted with cyano acetates to produce multisubstituted cyclohexanones in 60%~89%yields with 5∶1~>20∶1 dr.Under the same conditions,benzenedi(enones)underwent double Michael addition with cyano acetates or malononitrile to construct multisubstituted indanes in 77%~98%yields and>20∶1 dr.
作者
张阳
邢芬
冯泽男
杜广芬
顾承志
何林
Zhang Yang;Xing Fen;Feng Zenan;Du Guangfen;Gu Chengzhi;He Lin(School of Chemistry and Chemical Engineering,Shihezi University,Shihezi,Xinjiang 832000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第6期1608-1617,共10页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21662029)资助项目。
