摘要
目的探索超声造影测定达峰时间、峰值加速时间、增强速率与原发性肝癌患者组织学分化程度及癌细胞恶性行为的关系。方法选择2015年2月~2019年2月我院60例原发性肝癌患者作为研究对象,根据患者的组织分化程度,分为低分化程度患者21例,中分化程度患者19例,高分化程度患者20例。所有患者经过病理检查,Ⅰ~Ⅱ期组患者35例,Ⅲ~Ⅳ期组患者25例,淋巴转移患者32例。分析不同病理状态、组织分化程度以及淋巴转移情况的增始时间、峰值时间、峰值增强强度、增强速率以及50%倾斜率之间的差异。结果低分化组、高分化组以及中分化组患者的增始时间、峰值时间、峰值增强强度、增强速率以及50%倾斜率之间的差异有统计学意义(P<0.05)。经过两两比较,患者的峰值时间、增始时间、增强速率从高到低依次为高分化组、中分化组以及低分化组;患者的峰值时间、峰值增强强度以及50%倾斜率从高到低依次为低分化组、中分化组以及高分化组。Ⅲ~Ⅳ期组患者的增始时间、增强速率显著高于Ⅰ~Ⅱ期组(P<0.05),Ⅲ~Ⅳ期组患者的峰值时间、峰值增强强度以及50%倾斜率显著低于Ⅰ~Ⅱ期组(P<0.05)。淋巴转移组患者的增始时间、增强速率高于淋巴未转移组,淋巴转移组患者的峰值时间、峰值增强强度以及50%倾斜率低于淋巴未转移组(P<0.05)。患者的淋巴转移情况、病理状态以及组织分化程度分别于增始时间、增强速率呈现正相关,患者的淋巴转移情况、病理状态以及组织分化程度分别于峰值时间、峰值增强强度以及50%倾斜率呈现负相关(P<0.05)。结论超声造影测定达峰时间、峰值加速时间、增强速率与原发性肝癌患者的组织学分化程度及癌细胞恶性行为显著相关。
Objective To explore the relationship between the peak time, peak acceleration time, enhancement rate and the degree of histological differentiation and malignant behavior of cancer cells in PLC patients. Methods From February 2015 to February 2019, 60 patients with primary liver cancer were selected. According to the degree of tissue differentiation, there were21 patients with low differentiation, 19 patients with medium differentiation, 20 patients with high differentiation. All patients underwent pathological examination, 35 patients in stage Ⅰ-Ⅱ, 25 patients in stage Ⅲ-Ⅳ and 32 patients with lymph metastasis.To analyze the difference among the different pathological state, the degree of tissue differentiation and the condition of lymph node metastasis in the beginning time, peak time, peak enhancement intensity, enhancement rate and 50% tilt rate were compared. Results The differences of the starting time, peak time, peak enhancement intensity, enhancement rate and 50% tilt rate between the low differentiation group, the high differentiation group and the middle differentiation group were significant. The peak time, peak enhancement intensity and 50% tilt rate of the patients were divided into low differentiation group, middle differentiation group and high differentiation group. The time and rate of enhancement in the stage Ⅲ-Ⅳ group were significantly higher than those in the stageⅠ-Ⅱgroup. The peak time, peak intensity and 50% tilt rate in the stageⅢ-Ⅳgroup were significantly lower than those in the stageⅠ-Ⅱgroup. The time and rate of enhancement in the stageⅢ-Ⅳgroup were significantly higher than those in the stageⅠ-Ⅱgroup. The peak time, peak intensity and 50% tilt rate in the stageⅢ-Ⅳgroup were significantly lower than those in the stageⅠ-Ⅱgroup. In the group without lymph node metastasis, the lymph node metastasis, pathological state and the degree of tissue differentiation were positively correlated with the beginning time and the rate of enhancement respectively. The lymph node metastasis, pathological state and the degree of tissue differentiation were negatively correlated with the peak time, the peak intensity of enhancement and the 50% tilt rate respectively. Conclusion The peak time, peak acceleration time and enhancement rate measured by contrast-enhanced ultrasound are significantly related to the degree of histological differentiation and malignant behavior of cancer cells in patients with primary liver cancer.
作者
周俊宇
刘岚
ZHOU Junyu;LIU Lan(Department of Ultrasound,Chongming Branch,Xinhua Hospital Affiliated to Shanghai Jiaotong University,Shanghai 202150,China)
出处
《分子影像学杂志》
2020年第3期394-398,共5页
Journal of Molecular Imaging
关键词
超声造影
原发性肝癌
相关性
组织分化
contrast-enhanced ultrasonography
primary liver cancer
correlation
tissue differentiation
