摘要
目的探讨纤维蛋白原(FIB)联合D-二聚体(DD)检测在缺血性脑卒中早期筛查中的应用价值。方法选择2017年3月-2019年3月本院收治的134例缺血新脑卒中患者作为研究组,依据NIHSS(美国国立卫生研究院卒中量表)评分判定病情严重程度:45例轻度缺血性脑卒中,46例中度缺血性脑卒中,43例重度缺血性脑卒中;另选择同期在本院体检中心行健康体检者50例为健康对照组。经免疫比浊法对2组人员血浆纤维蛋白原表达实施测定,经双抗体夹心法对2组人员血浆D-二聚体表达实施测定,探讨血浆FIB、DD表达和神经功能缺损NIHSS评分相关性。结果研究组患者的血浆FIB、DD表达均高于健康对照组,差异有统计学意义(P<0.05);重度组、中度组患者的血浆FIB表达、DD表达、NIHSS评分均高于轻度组,重度组高于中度组,差异有统计学意义(P<0.05);经Pearson相关性分析发现,血浆FIB、DD表达和缺血性脑卒中患者NIHSS评分均显示为正相关(r值分别为0.685、0.767,P<0.05)。结论缺血性脑卒中患者的血浆纤维蛋白原、D-二聚体表达异常增高,联合检测血浆FIB、DD表达能为临床诊断缺血性脑卒中及判定病情进展提供指导,利于临床早期制定防治措施。
Objective To investigate the value of fibrinogen(FIB)combined with D-dimer(DD)detection in early screening for ischemic stroke.Methods A total of 134 patients with ischemic stroke who were admitted to our hospital from March 2017 to March 2019 were enrolled as the study group.The severity of the disease was determined according to the NIHSS(American National Institutes of Health Stroke Scale)score,including 45 cases of mild ischemic stroke,46 cases of moderate ischemic stroke,and 43 cases of severe ischemic stroke;In addition,50 cases of normal people for physical examination were selected as the control group.The plasma fibrinogen expression of the two groups was determined by immunoturbidimetry,and the plasma D-dimer expression was measured by double antibody sandwich method to investigate the correlation between plasma FIB,DD expression and NIHSS scores of neurological deficits.Results The plasma levels of FIB and DD in the study group were higher than those in the control group,with the differences statistically significant(P<0.05).The plasma FIB expression,DD expression and NIHSS scores of the severe group and the moderate group were higher than those of the mild group,and the severe group was higher than the moderate group,with the differences statistically significant(P<0.05).Pearson correlation analysis showed that plasma FIB,DD expression and NIHSS scores in patients with ischemic stroke showed positive correlation(r=0.685,r=0.767,P<0.05).Conclusion The expression of plasma fibrinogen and D-dimer in patients with ischemic stroke is abnormally increased.Combined detection of plasma FIB and DD expression can provide guidance for the clinical diagnosis of ischemic stroke and determination of disease progression,which is conducive to the development of preventive interventions in the early stages of clinical practice.
作者
卢晓敏
徐炜斐
张春霞
LU Xiao-min;XU Wei-fei;ZHANG Chun-xia(Emergency Department,Yiwu Hospital of Traditional Chinese Medicine,Yiwu,Zhejiang 322000,China)
出处
《中国卫生检验杂志》
CAS
2020年第12期1491-1493,共3页
Chinese Journal of Health Laboratory Technology
