摘要
目的探讨人工肝血浆置换术治疗肝衰竭的临床效果。方法选取2013年3月~2019年3月我院收治的88例肝衰竭患者作为研究对象,按照随机数字表法分为A组(44例)与B组(44例)。A组采用内科综合治疗方法,B组在A组的基础上行人工肝血浆置换术治疗,比较两组的临床疗效、肝功能指标、炎性因子水平。结果治疗2周后,B组的好转率为75.00%,高于A组的40.90%,差异有统计学意义(P<0.05);治疗后,B组的血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBil)与血清白介素(IL)-17、IL-12、IL-35水平低于A组,差异有统计学意义(P<0.05)。结论人工肝血浆置换术治疗肝衰竭效果显著,可有效改善患者肝功能,并缓解机体炎性反应。
Objective To explore the clinical effect of artificial liver plasma exchange in the treatment of liver failure.Methods A total of 88 patients with liver failure who were admitted to the hospital fron March 2013 and March 2019 were selected as the subjects.They were divided into group A(44 cases)and group B(44 cases)by the random number table method.Groups A was given comprehensive medical treatment,and group B were additionally treated with artificial liver plasma exchange on the basis of group A.The clinical effect,levels of liver function indicators and inflammatory factors were compared between the two groups.Results After 2 weeks of treatment,the improvement rate in group B was 75.00%,which was higher than that in group A(40.90%),the difference was statistically significant(P<0.05).After treatment,the levels of serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBil),and serum interleukin(IL)-17,IL-12,and IL-35 in group B were lower than those in group A,the differences were statistically significant(P<0.05).Conclusion The effect of artificial liver plasma exchange is significant in the treatment of liver failure.It can effectively improve the liver function of patients and relieve inflammatory response.
作者
李清奇
郭婷
张丽丽
王伟新
LI Qing-qi;GUO Ting;ZHANG Li-li;WANG Wei-xin(The Second Affiliated Hospital of Yichun College,Jiangxi Province,Yichun 336000,China)
出处
《中国当代医药》
2020年第17期40-42,共3页
China Modern Medicine
基金
江西省宜春市科技计划项目(JXYC2019KSA021)。
关键词
人工肝血浆置换术
内科综合治疗
肝衰竭
疗效
炎性因子
Artificial liver plasma exchange
Comprehensive medical treatment
Liver failure
Curative effect
Inflammatory factor
