摘要
目的:探讨血浆灌流(PP)治疗对肝衰竭患者循环血中T淋巴细胞亚群及炎性因子水平表达的影响及临床意义。方法:以112例肝衰竭患者作为治疗组,选取同期HBsAg(-)的健康体检者25例为对照组,检测在PP治疗前后循环血中CD4+T、CD8+T及炎性因子中的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-10、γ-干扰素(IFN-γ)的水平表达。结果:治疗组患者在采用PP治疗后,TBIL、ALT、PTA、CRP的表达水平较治疗前明显下降(P<0.05)。治疗组患者采用PP治疗前,CD4+T、CD8+T水平较对照组低表达,CD4+T/CD8+T比值高表达,差异有统计学意义(P<0.05)。治疗组患者在PP治疗后,CD4+T、CD8+T水平较治疗前明显上调,CD4+T/CD8+T比值明显下调,差异有统计学意义(P<0.05);CD4+T、CD8+T水平较对照组明显下调,CD4+T/CD8+T比值明显上调,差异有统计学意义(P<0.05)。治疗组患者在PP治疗前,TNF-α、IFN-γ、IL-6、IL-10水平较对照组明显上调,差异有统计学意义(P<0.05);治疗组患者在PP治疗后TNF-α、IFN-γ、IL-6、IL-10水平较治疗前明显下调,差异有统计学意义(P<0.05);治疗组患者在PP治疗后TNF-α、IFN-γ、IL-6、IL-10水平较对照组明显上调,差异有统计学意义(P<0.05)。结论:PP治疗肝衰竭患者可显著调控循环血中T淋巴细胞亚群的失衡状态,调节紊乱的炎性因子水平,促进肝功能复常,提高肝衰竭患者存活率。
Objective:To investigate the effect of Plasma perfusion(PP)on the levels of T lymphocyte subgroup and inflammatory factors in circulating blood of patients with hepatic failure and its clinical significance.Methods:112 patients with liver failure were selected as the treatment group,and 25 healthy persons with HBsAg(-)in the same period were selected as the control group.The levels of CD4+T,CD8+T and tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),ifn-interferon(IFN-γ)in circulating blood before and after PP treatment were detected.Results:The expression levels of TBIL,ALT,PTA and CRP were significantly decreased in the treatment group after PP treatment compared with that before treatment(P<0.05).The CD4+T and CD8+T levels in the treatment group were lower than those in the control group before PP treatment,and the CD4+T/CD8+T ratio was higher,with statistically significant differences(P<0.05).In the treatment group,CD4+T and CD8+T levels were significantly up-regulated after PP treatment,and CD4+T/CD8+T ratio was significantly down-regulated,with statistically significant differences(P<0.05).After PP treatment,CD4+T and CD8+T levels in patients in the treatment group were significantly lower than those in the control group,and the CD4+T/CD8+T ratio was significantly up-regulated,with statistically significant differences(P<0.05).The levels of TNF-α,IFN-γ,IL-6 and IL-10 in the treatment group were significantly higher than those in the control group(P<0.05),the levels of TNF-α,IFN-γ,IL-6 and IL-10 in the treatment group were significantly lower than those in the control group(P<0.05),the levels of TNF-α,IFN-γ,IL-6 and IL-10 in the treatment group were significantly higher than those in the control group(P<0.05),the difference was statistically significant(P<0.05).Conclusion:PP treatment for liver failure patients can significantly regulate the imbalance of T lymphocyte subsets in circulating blood,regulate the level of disordered inflammatory factors,promote the recovery of liver function,and improve the survival rate of liver failure patients.
作者
任亮
喻雪琴
陈星
陈芳
梅怡晗
敬雪明
REN Liang;YU Xue-qin;CHEN Xing;CHEN Fang-;MEI Yi-han;JING Xue-ming(Department of Infection,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan;Capital Medical University,Beijing 100054;Department of Nephrology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)
出处
《川北医学院学报》
CAS
2020年第3期505-508,共4页
Journal of North Sichuan Medical College
关键词
血浆灌流
炎性细胞因子
T淋巴细胞
乙肝病毒
肝衰竭
Plasma perfusion
Inflammatory cytokines
T lymphocytes
Hepatitis B virus
Liver failure
