摘要
乙型肝炎病毒血清学标志物检测在乙肝流行病学调查、疾病诊断与预后判断、抗病毒疗效监测与预测、乙肝疫苗效果评价等方面发挥着重要的作用,而检测技术的不断进步是保证检测结果准确性的重要保障。本文系统回顾性的总结了对流免疫电泳、红细胞凝集试验、放射免疫分析试验、酶联免疫吸附试验、固相膜免疫分析技术、化学发光免疫分析技术的原理、特点及其在乙肝血清学标志物检测中的应用现状,重点对化学发光免疫检测系统在乙肝血清标志物定量检测的应用前景进行了分析与展望。
The detection of hepatitis B virus serological markers plays an important role in the inves-tigation of hepatitis B epidemiology,disease diagnosis and prognosis,antiviral efficacy monitoring and predic-tion,and the evaluation of the effect of hepatitis B vaccination.The continuous improvement of detection tech-nology is necessary to guarantee the accuracy of results.This article systematically summarizes the principles and characteristics of counter immunoelectrophoresis,erythrocyte agglutination test,radioimmunoassay test,en-zyme-linked immunosorbent assay,solid-phase membrane immunoassay technology,chemiluminescence im-munoassay technology and their serologic al markers in hepatitis B and the current status of the application.The focus is on the analysis and prospect of the application of chemiluminescent immunoassay system in the quantita-tive detection of hepatitis B serum markers.
作者
张学东
卢建华
王梦寒
戴二黑
ZHANG Xuedong;LU Jianhua;WANG Menghan;DAI Erhei(Autobio Diagnostics Co.,Ltd,Zhengzhou,Henan,China,450016;The Fifth Hospital of Shijiazhuang,Shijiazhuang,Hebei,China,050000)
出处
《分子诊断与治疗杂志》
2020年第6期693-696,F0002,共5页
Journal of Molecular Diagnostics and Therapy
基金
石家庄市科学技术研究与发展指导计划(151460653)。
关键词
HBV
血清学
标志物
检测技术
Hepatitis B virus
Serum
Markers
Detecting technique
