摘要
目的观察青年首发抑郁症患者皮质醇与脑电图(EEG)及认知功能的相关性。方法选择2018年1月~2019年6月浙江省宁波市康宁医院(以下简称"我院")门诊就诊的46例首发青年抑郁症患者为研究对象,按皮质醇水平差异以均数557 nmol/L分为低皮质醇组(18例,皮质醇≤557 nmol/L)、高皮质醇组(28例,皮质醇>557 nmol/L)。收集患者一般资料、韦氏记忆量表(WMS)评分、EEG分析等数据,分析不同皮质醇水平时表现差异,并分析WMS评分、脑电图异常表现与皮质醇水平相关性。结果两组一般临床资料(年龄、性别、体重指数、学历水平)比较差异无统计学意义(P> 0.05)。低皮质醇组WMS均分及分级情况高于高皮质醇组,差异有统计学意义(P <0.05)。低皮质醇组EEG异常表现(θ波、δ波、额颞棘波、额颞尖波、快慢结合波、痫样放电波)的发生率低于高皮质醇组。EEG异常与皮质醇水平均呈正相关(r=0.786、0.627、0.774、0.784、0.681、0.735,P <0.05),WMS评分与皮质醇水平呈负相关(r=-0.816,P <0.05)。结论首发青年抑郁症患者存在认知功能变化,以广泛性慢波、14~20 Hz快波、痫样放电波等为主要EEG异常表现,且认知功能变化、EEG异常的程度与皮质醇水平有关,值得临床重视与关注。
Objective To observe the relationship between cortisol,electroencephalogram(EEG)and cognitive function in young patients with first-episode depression.Methods From January 2018 to June 2019,46 patients with first-episode depression in the outpatient clinic of Ningbo Kangning Hospital("our hospital"for short)were selected as the study subjects.According to the average cortisol level(557 nmol/L),they were divided into low cortisol group(18 cases,cortisol≤557 nmol/L)and high cortisol group(28 cases,cortisol>557 nmol/L).The general data,wechsler memory scale(WMS)score and EEG data of all patients were collected,and the difference at different cortisol levels were analyzed.The correlation between WMS score,abnormal EEG performance and cortisol levels were analyzed.Results There were no significant difference in general clinical data(age,sex,body fat ratio,education level)between low cortisol group and high cortisol group(P>0.05).The average score and classification of WMS in the low cortisol group were higher than those in the high cortisol group,and the differences were statistically significant(P<0.05).The incidence of abnormal EEG performance(θwave,δwave,frontotemporal spike wave,frontotemporal cusp wave,fast-slow combined wave,epileptiform discharge wave)in the low cortisol group was lower than that in the high cortisol group.Abnormalities in EEG were positively correlated with the cortisol level(r=0.786,0.627,0.774,0.784,0.681,0.735,P<0.05).The WMS score was negatively correlated with the cortisol level(r=-0.816,P<0.05).Conclusion There are changes in cognitive function in the first-onset young patients with depression.The main manifestations of EEG abnormalities are widespread slow wave,14-20 HZ fast wave,and epileptiform discharge wave.Changes in cognitive function and the degree of EEG abnormalities are related to cortisol levels,which deserves clinical attention.
作者
邱正法
华玖州
田海华
QIU Zhengfa;HUA Jiuzhou;TIAN Haihua(Dpartment of Special Survey Division,Ningbo Kangning Hospital,Zhejiang Province,Ningbo 315201,China;Department of Psychological Testing,Ningbo Kangning Hospital,Zhejiang Province,Ningbo 315201,China;Clinic Laboratory of Ningbo Kangning Hospital,Zhejiang Province,Ningbo 315201,China)
出处
《中国医药导报》
CAS
2020年第17期137-140,共4页
China Medical Herald
基金
浙江省医药卫生科技计划项目(2019KY628)。
关键词
首发抑郁症
青年
皮质醇
脑电图特征
认知功能
First episode depression
Youth
Cortisol
Electroencephalogram characteristics
Cognitive function
