摘要
目的探讨脑卒中干细胞移植的有效性并分析不同方法对其功能重构的影响。方法计算机检索PubMed、EMbase、Medline、the Cochrane library、中国知网和万方、维普数据库中关于干细胞移植改善脑卒中患者功能缺损的研究,检索时间为建库至2019年5月。根据纳入标准筛选评估文献后,提取各组美国国立卫生研究院卒中量表(NIHSS)评分进行合并分析。结果最终纳入11项临床对照试验,共计657例患者。直接meta分析结果显示:与对照组(生理盐水或常规治疗)比较,试验组(干细胞移植)NIHSS升高,差异有统计学意义[MD=-2.37,95%CI:(-2.79,-1.97),P <0.05]。网状meta分析结果显示:不同干细胞移植方式疗效:动脉>静脉+其他方式>非静脉移植>静脉组;不同干细胞移植时期疗效:急性期>慢性期。结论脑卒中后移植干细胞有利于改善卒中患者受损功能,干细胞移植途径、移植时间能够影响卒中后神经功能恢复。
Objective To review the effect of stem cell transplantation in the treatment of neurologic deficit and different methods of cell transplantationon functional remodeling after stroke.Methods Control trails about the effect of stem cell transplantation on after neurologic deficitstroke were searched and evaluated from PubMed,EMbase,Medline,the Cochrane library,CNKI and WanFang,VIP database.The retrieval time was from the database to May 2019.After screening and evaluating the literatures according to the inclusion criteria,the national institutes of health stroke scale(NIHSS)scores of each group were extracted for combined analysis.Results A total of 11 studies with 567 participants totally were included.The results of direct meta-analysis showed that the scores of NIHSS in the experinrental group(stem cell transplantation)was higher than the control group(normal saline or conventional treatment),the difference was statistically significant(MD=-2.37,95%CI:[-2.79,-1.97],P<0.05).The results of network meta-analysis showed the efficacy of different cell transplantation methods:arterial>vein+other way>non-venous transplantation>vein and different period:acute>chronic.Conclusion Stem cell transplantation is beneficial to improve the impaired function for stroke patients,andthedifferent way and time of cell transplantation can affect the recovery of nerve function.
作者
王露露
高润
刘莉
WANG Lulu;GAO Run;LIU Li(Department of Brain Rehabilitation,Hospital Affiliated to Nanjing Medical University,Jiangsu Province,Nanjing 210029,China)
出处
《中国医药导报》
CAS
2020年第17期91-95,共5页
China Medical Herald
基金
江苏省南京市医学科技发展重点项目(ZKX17029)。
关键词
脑卒中
干细胞移植
功能缺损
META分析
Stroke
Stem cell transplantation
Functional deficit
Meta-analysis
