摘要
围术期神经认知障碍(PND)是指患者围手术期发生的神经认知功能改变,临床上尚缺乏有效的防治策略。近年来,右美托咪定(Dex)因其抑制炎症反应、抗交感、脑保护作用而被用于PND的防治。本文回顾总结Dex防治PND的相关研究,阐述Dex防治PND临床研究进展和机制进展,Dex防治PND的用药时机、剂量以及作用机制仍需进一步探讨。
Perioperative neurocognitive disorders(PND)refers to the changes in patients neurocognitive functions during perioperative period.Clinically,there is a lack of effective prevention and treatment strategies.In recent years,dexmedetomidine(Dex)has been used in the prevention and treatment of PND due to its effect on the suppression of inflammation,anti-sympathetic activity and brain protection.The related studies on the prevention and treatment of PND with Dex were reviewed,the clinical research progress and mechanism of the prevention and treatment of PND with Dex were described.The timing and dosage of the prevention and treatment of PND with Dex and the mechanism of action still need to be further discussed.
作者
贾谜谜
闫琪
马尚文
阎文军
JIA Mimi;YAN Qi;MA Shangwen;YAN Wenjun(Graduate School,Gansu University of Chinese Medicine,Lanzhou 730000;Graduate School,Ningxia Medical University,Yinchuan 750000;Anesthesia Operation Department,Gansu Provincial Hospital,Lanzhou 730000,China)
出处
《麻醉安全与质控》
2020年第4期240-244,共5页
Perioperative Safety and Quality Assurance
基金
国家自然科学基金(81560214,81860233)
甘肃省卫生行业科研计划项目(GSWSKY-2015-01)。
关键词
右美托咪定
围术期神经认知障碍
术后谵妄
研究进展
dexmedetomidine
perioperative neurocognitive disorders
postoperative delirium
research progress
