摘要
目的探讨妊娠合并支气管哮喘急性发作的危险因素。方法回顾性分析2017年5月至2019年5月因妊娠合并支气管哮喘到琼海市人民医院治疗的128例患者的临床资料,根据支气管哮喘诊断标准分为发作组与未发作组,采用多因素Logistic回归分析妊娠合并支气管哮喘急性发作的影响因素。结果128例患者中发作56例(43.75%)。Logistic回归分析显示孕周≥14周,合并感染、不使用哮喘控制药物、焦虑、抑郁、维生素D<25.24 ng/mL、血清IgE>112.58 IU/mL、白介素-17(IL-17)>82.39 ng/L是妊娠合并支气管哮喘急性发作的独立危险因素,差异有统计学意义(P<0.05)。结论孕周≥14周,合并感染、不使用哮喘控制药物、焦虑、抑郁、维生素D<25.24 ng/mL、血清IgE>112.58 IU/mL、IL-17>82.39 ng/L是妊娠合并支气管哮喘急性发作的独立危险因素,对于这类患者临床上应给予重视。
Objective To explore the risk factors of acute exacerbation of bronchial asthma during pregnancy.Methods The clinical data of 128 patients who came to Qionghai People's Hospital from May 2017 to May 2019 due to pregnancy combined with bronchial asthma were analyzed retrospectively.According to the diagnostic criteria of bronchial asthma,they were divided into attack group and non-attack group.The influencing factors of pregnancy combined with acute attack of bronchial asthma were analyzed by multivariate logistic regression.Results Among 128 patients,56(43.75%)had attacks.Logistic regression analysis showed that gestational weeks≥14 weeks,with infection,without asthma control drugs,anxiety,depression,vitamin D<25.24 ng/mL,serum IgE>112.58 IU/mL,IL-17>82.39 ng/L were independent risk factors for acute attacks of gestational asthma(P<0.05).Conclusion The gestational weeks≥14 weeks,infection,non use of asthma control drugs,anxiety,depression,vitamin D<25.24 ng/mL,serum IgE>112.58 IU/mL,IL-17>82.39 ng/L are the independent risk factors for the acute attack of asthma in pregnancy.We should pay attention to these patients in clinic.
作者
黎天皇
李翠
孙乐标
吴勤练
LI Tianhuang;LI Cui;SUN Yuebiao;WU Qinlian(Department of Emergency,Qionghai People's Hospital,Qionghai Hainan 571400,P.R.China;Department of Obstetrics,Qionghai People's Hospital,Qionghai Hainan 571400,P.R.China)
出处
《中国计划生育和妇产科》
2020年第6期87-91,共5页
Chinese Journal of Family Planning & Gynecotokology
关键词
妊娠
支气管哮喘
急性发作
危险因素
pregnancy
bronchial asthma
acute attack
risk factors
