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特发性肺纤维化与细胞微环境之间关系的研究进展 被引量：9

Relationship between Cellular Microenvironment and Idiopathic Pulmonary Fibrosis
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摘要 特发性肺纤维化(IPF)是一种以肺间质纤维化和肺功能损害为特点的进行性发展的肺部疾病。细胞微环境主要由不同类型的细胞成分、细胞外基质、细胞外调节分子和液体物质组成。现代研究发现,微环境成分的变化与IPF发生关系密切。本文从细胞微环境中细胞调节因子、间充质细胞、细胞外基质、未折叠蛋白4个方面阐述IPF的发病机制。 Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease characterized by pulmonary interstitial fibrosis and pulmonary dysfunction.Cell microenvironment is mainly composed of cell components,extracellular matrix,extracellular regulators,and liquid substances.Changes in microenvironment components are closely related to IPF.This article elaborates the roles of cell microenvironments including cytokines,mesenchymal cells,extracellular matrix,and unfolded proteins in the pathogenesis of IPF.
作者 叶威 孙梦阳 王新华 YE Wei;SUN Mengyang;WANG Xinhua(First Clinical Medical College,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China)
机构地区 浙江中医药大学第一临床医学院
出处 《中国医学科学院学报》 CAS CSCD 北大核心 2020年第3期410-416,共7页 Acta Academiae Medicinae Sinicae
关键词 特发性肺纤维化 细胞微环境 细胞调节因子 间充质细胞 细胞外基质 未折叠蛋白反应 idiopathic pulmonary fibrosis cellular microenvironment cyto-regulatory factor mesenchymal cells extracellular matrix unfolded protein response
分类号 R563.9 [医药卫生—呼吸系统]
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中国医学科学院学报
2020年 第3期

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