摘要
目的探讨三酰甘油(TG)/高密度脂蛋白胆固醇(HDL-C)比值与2型糖尿病合并骨质疏松的关系。方法选取2018年4月~2019年4月于我院住院的186例2型糖尿病患者作为研究对象,依据双能X线骨密度仪检测的患者腰椎及左侧股骨近端骨密度的不同,将其分为骨量正常组(64例)、骨量减少组(77例)、骨质疏松组(45例)。采集三组患者的静脉血,检测空腹血糖(FBG)、尿酸(UA)、TG、总胆固醇(TC)、HDL-C、低密度脂蛋白胆固醇(LDL-C)、胱抑素C(CysC)、血清糖化血红蛋白(HbA1c)。采用单因素方差分析和Pearson相关性分析TG/HDL-C比值与骨密度的相关性。结果骨质疏松组患者的体重指数(BMI)、UA、TG、TG/HDL-C低于骨量减少组及骨量正常组,差异有统计学意义(P<0.05)。骨质疏松组患者的糖尿病病程长于骨量减少组及骨量正常组,HDL-C、LDL-C、CysC高于骨量减少组及骨量正常组,差异有统计学意义(P<0.05)。骨量减少组患者的BMI、UA、TG、TG/HDL-C低于骨量正常组,差异有统计学意义(P<0.05)。骨量减少组患者的糖尿病病程长于骨量正常组,HDL-C、LDL-C、CysC高于骨量正常组,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,TG/HDL-C与2型糖尿病患者腰椎L1~4、左侧股骨颈、股骨大转子、Wards三角、全部股骨的骨密度均成正相关(r=0.275、0.281、0.276、0.268、0.287,P<0.001)。结论低TG/HDL-C与2型糖尿病合并骨质疏松的发生风险增加存在相关性。
Objective To investigate the correlation between the ratio of triglyceride(TG)to high density lipoprotein cholesterol(HDL-C)and patients with type 2 diabetes complicated with osteoporosis.Methods A total of 186 hospitalized patients with type 2 diabetes in our hospital from April 2018 to April 2019 were selected as subjects.According to the differences in bone mineral density of lumbar spine and proximal end of left femur detected by dual energy x-ray absorptiometry,the patients were divided into normal bone mass group(64 cases),osteopenia group(77 cases)and osteoporosis group(45 cases).Venous blood was collected from patients in the three groups,and fasting blood glucose(FBG),uric acid(UA),TG,total cholesterol(TC),HDL-C,low-density lipoprotein cholesterol(LDL-C),cystatin C(CysC),and serum glycosylated hemoglobin(HbA1c)were detected.The correlation between the ratio of TG/HDL-C and bone mineral density was analyzed by One-way analysis of variance and Pearson correlation.Results The body mass index(BMI),UA,TG and TG/HDL-C of the osteoporosis group were lower than those of the osteopenia group and the normal bone mass group,and the differences were statistically significant(P<0.05).The duration of diabetes in the osteoporosis group was longer than that in the osteopenia group and the normal bone mass group,HDL-C,LDL-C and CysC were higher than those in the osteopenia group and the normal bone mass group,and the differences were statistically significant(P<0.05).BMI,UA,TG and TG/HDL-C in the osteopenia group were lower than those in the normal bone mass group,with statistically significant differences(P<0.05).The duration of diabetes in the osteopenia group was longer than that in the normal bone mass group,and HDL-C,LDL-C and CysC were higher than those in the normal bone mass group,with statistically significant differences(P<0.05).Pearson correlation analysis results showed that TG/HDL-C was positively correlated with bone mineral density of lumbar L1-4,left femoral neck,femoral trochanter,wards triangle and all femur in patients with type 2 diabetes(r=0.275,0.281,0.276,0.268,0.287,P<0.001).Conclusion Low TG/HDL-C is related to the increased risk of type 2 diabetes complicated with osteoporosis.
作者
何圣清
郑晓斌
武红梅
HE Sheng-qing;ZHENG Xiao-bing;WU Hong-mei(Department of Endocrinology,Longgang Central Hospital of Shenzhen City,Guangdong Province,Shenzhen 518116,China)
出处
《中国当代医药》
2020年第16期113-116,共4页
China Modern Medicine
