摘要
目的分析北京地区航天系统职工幽门螺杆菌(H.pylori)的感染状况,以及与血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ/PGⅡ(PGR)和代谢综合征(MS)各项指标的相关性。方法对2018年1-12月于航天中心医院健康管理部进行健康体检的4750名航天系统职工的体检资料进行回顾性分析。根据13碳-呼气试验(13CUBT)的检测结果,分析该人群H.pylori的感染特征,并将人员分为H.pylori阳性组和H.pylori阴性组,比较两组人员血清PGⅠ、PGⅡ、PGR和MS的诊断率及各项代谢指标:空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度胆固醇(HDL-C)、低密度胆固醇(LDL-C)、尿酸(UA)、体重指数(BMI)等水平的差异,分析H.pylori感染与上述指标的相关性。结果4750名航天系统职工H.pylori感染率为25.8%(1225/4750),MS诊断率为14.2%(673/4750)。H.pylori阳性组血清中PGR(4.89±1.52)和HDL-C(1.07±0.46)mmol/L水平低于阴性组(5.23±1.67)、(1.11±0.46)mmol/L,MS检出率(16.2%)及TG水平(1.53±1.46)mmol/L高于阴性组(13.5%)、(1.41±1.53)mmol/L,差异均有统计学意义(P均<0.05)。两组PGⅠ、PGⅡ、BMI、FBG、TC、LDL-C、UA比较差异均无统计学意义(P>0.05)。Pearson相关性分析显示,H.pylori感染与TG水平呈正相关(r=0.551,P<0.05),与PGR和HDL-C呈负相关(r=-0.542、-0.443,P<0.05)。结论幽门螺杆菌感染与血清胃蛋白酶原和代谢综合征有相关性,检测幽门螺杆菌感染对于胃部疾病和代谢性疾病的防治有重要意义。
Objective To analyze Helicobacter pylori(H.pylori)infection and the correlation with serum pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and PGⅠ/PGⅡ(PGR)and indexes of metabolic syndrome(MS)in aerospace staff in Beijing.Methods A retrospective study was conducted based on the data from 4750 aerospace staff.The prevalence of Helicobacter pylori infection was studied.According to the presence of H.pylori infection,the subjects were divided into H.pylori-positive group and H.pylori-negative group.The indexes of serum PGⅠ,PGⅡ,PGR and indexes of metabolism fasting blood glucose(FBG),triacylglycerol(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),uric acid(UA),body mass index(BMI)were compared between two groups.The correlation between H.pylori infection and the above indexes were analyzed.Results Among the 4750 subjects,1225 were H.pylori-positive and the positive rate was 25.8%;673 were diagnosed MS and the positive ratio was 14.2%.The levels of serum PGR and HDL-C were lower,while MS ratio and TG level were higher in H.pylori-positive group[(4.89±1.52),(1.07±0.46)mmol/L,16.2%,(1.53±1.46)mmol/L]than H.pylori-negative group[(5.23±1.67),(1.11±0.46)mmol/L,13.5%,(1.41±1.53)mmol/L](P<0.05).There was no significant difference in PGⅠ,PGⅡ,BMI,FBG,TC,LDL-C,UA between the two groups(P>0.05).Pearson correlation analysis showed that H.pylori infection was positively correlated with TG level(r=0.551,P<0.05),and negatively correlated with PGR and HDL-C(r=-0.542,-0.443,P<0.05).Conclusions H.pylori infection might affect serum pepsinogen and related with MS.Diagnosis,prevention and curing of H.pylori infection should be important in guaranteeing the health of aerospace staff.
作者
郭丽萍
郝燕菲
马志红
王婧
GUO Li-ping;HAO Yan-fei;MA Zhi-hong;WANG Jing(Department of Health Management,Aerospace Center Hospital,Beijing 100049,China)
出处
《热带医学杂志》
CAS
2020年第4期546-549,共4页
Journal of Tropical Medicine
