摘要
目的探讨卡巴拉汀联合多奈哌齐治疗老年痴呆的临床疗效.方法将135例老年痴呆患者按随机数字表法分为卡巴拉汀组、多奈哌齐组和联合组,各45例.3组均给予常规治疗及护理,在此基础上卡巴拉汀组给予卡巴拉汀治疗,多奈哌齐组给予多奈哌齐治疗,联合组给予卡巴拉汀联合多奈哌齐治疗,观察16周.比较3组丙二醛、超氧化物歧化酶水平,采用阿尔茨海默病行为病理评定量表、临床痴呆量表、神经精神症状问卷评定精神行为症状,采用蒙特利尔认知功能量表评定认知功能,采用日常生活自理量表评定患者的生活能力,统计并比较3组不良发应发生率.结果治疗后3组丙二醛水平较治疗前显著降低(P<0.05),超氧化物歧化酶水平较治疗前显著升高(P<0.05),联合组较其余两组变化更显著(P<0.05).(2)治疗后3组阿尔茨海默病行为病理评定量表、临床痴呆量表、神经精神症状问卷及日常生活自理量表评分均较治疗前显著降低(P<0.05),联合组显著低于其余两组(P<0.05);3组蒙特利尔认知功能量表评分较治疗前显著升高(P<0.05),联合组显著高于其余两组(P<0.05).3组不良反应发生率比较差异无统计学意义(P>0.05).结论卡巴拉汀联合多奈哌齐治疗老年痴呆患者疗效显著,能够有效抑制氧化应激反应,改善精神行为症状、认知障碍,提高其日常生活能力,安全性高.
Objective To explore the effects of rivastigmine and donepezil in the treatment of senile dementia.Methods A total of 135 patients with senile dementia were included and randomly divided into rivastigmine group(n=45),donepezil group(n=45)and combined group(n=45).All three groups were given routine therapy and nuring,and rivastigmine group was treated with rivastigmine,and donepezil group was given donepezil,and combined group was given rivastigmine+donepezil,and they were treated for 16 weeks.Compare the levels of MDA and SOD in the three groups,use BEHAVE-AD,CDR,and NPI to evaluate mental and behavioral symptoms,use MoCA to evaluate cognitive function,and use ADL to evaluate patients'living ability.The incidence of adverse reactions in the three groups was compared.Results The levels of MDA in the three groups were significantly lower than those before treatment(P<0.05),and the levels of SOD were significantly higher than those before treatment(P<0.05).The combination group had more significant changes than the other two groups(P<0.05).After treatment,the BEHAVE-AD,CDR,NPI and ADL scores of the three groups were significantly lower than before treatment(P<0.05),and the combined group was significantly lower than the other two groups(P<0.05).The MoCA scores of the three groups were significantly higher than before treatment(P<0.05),and the combined group was significantly higher than the other two groups(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusions Rivastigmine combined with donepezil for patients with senile dementia can inhibit oxidative stress reactions,improve mental and behavioral symptoms,cognitive impairment,and improve their daily living ability,and have highly safe.
作者
胡春丽
何传才
常青
Hu Chunli;He Chuancai;Chang Qing(Shangqiu Second People's Hospital,Shangqiu 476000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2020年第3期34-37,共4页
Journal of Clinical Psychosomatic Diseases
关键词
老年痴呆
卡巴拉汀
多奈哌齐
精神行为症状
认知障碍
日常生活能力
Alzheimer's disease
rivastigmine
donepezil
behavioral and psychological symptoms
cognitive disorders
daily living ability
