摘要
目的探讨丙硫氧嘧啶与甲巯咪唑用于Graves病甲状腺功能亢进症患者治疗中的效果分析。方法从2017年10月~2019年10月在我院治疗的甲状腺功能亢进症患者200例中择取70例Graves病甲状腺功能亢进症患者作为基础研究数据,按随机原则分成对照组(n=35)及观察组(n=35),对照组采取丙硫氧嘧啶,观察组采用甲硫咪唑方案,分析组间治疗效果、甲状腺体积变化指标、药物使用后的不良反应率。结果观察组治疗总有效率、治疗前后甲状腺体积变化幅度与对照组差异均无统计学意义(P>0.05);观察组治疗后3个月不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论Graves病甲状腺功能亢进症的治疗中使用丙硫氧嘧啶与甲巯咪唑两种药物,临床各项指标的改善情况均较为理想,可以将疾病控制在更加理想的范围内,可结合患者实际情况选择药物。
Objective To investigate the effect of propylthiouracil and methimazole in the treatment of patients with Graves hyperthyroidism.Methods 70 patients with Graves hyperthyroidism from 200 patients with hyperthyroidism treated in our hospital from October 2017 to October 2019 were selected as basic research subjects and divided into the control group(n=35)and the observation group(n=35)according to the random principle.The control group was treated with propylthiouracil.The observation group was treated with methimazole.The treatment effects,indicators of thyroid volume change,and adverse reaction rates after drug use between groups were analyzed.Results There was no significant difference in the total effective rate of treatment,the change in thyroid volume before and after treatment between the observation group and the control group(P>0.05).The incidence of adverse reactions at 3 months after treatment in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The propylthiouracil and methimazole in the treatment of Graves hyperthyroidism can make the improvement of clinical indicators satisfactory.The disease can be controlled in a more ideal range and one drug can be chosen combined with the actual situation of patients.
作者
冯耀然
FENG Yaoran(Department of Endocrinology,Shunde Hospital of Southern Medical University,Foshan Shunde First People's Hospital in Guangdong Province,Foshan 528300,China)
出处
《中国现代医生》
2020年第12期122-124,128,共4页
China Modern Doctor
