摘要
目的探讨糖尿病病程与糖尿病视网膜病变的相关性。方法选择2018年1~6月在医院诊断治疗的2型糖尿病患者150例为研究对象。根据患者是否合并有糖尿病视网膜病变分为NDR组、NPDR组与PDR组。记录患者一般资料及临床资料,包括年龄、性别、BMI、吸烟、空腹血糖(FBG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、糖尿病病程、血脂水平(TG、TC、HDL-C、LDL-C)水平。分析糖尿病视网膜病变,并分析糖尿病病程与糖尿病视网膜病变的相关性。结果(1)150例患者82例发生DR,发生率54.67%。其中63例为NPDR,占76.83%,19例为PDR,占23.17%。(2)PDR组FBG、2hPG、HbA1c、TC、TG、LDL-C水平最高,HDL-C水平最低,其次为NPDR组,三组间比较差异有统计学意义(P<0.05)。PDR组病程最长,其次为NPDR组,NDR组最短,差异有统计学意义(P<0.05)。(3)多因素分析结果显示,糖尿病病程、FBG、2hPG、TC、TG、LDL-C是糖尿病患者视网膜病变的独立危险因素(P<0.05),HDL-C是保护因素(P<0.05)。(4)病程与糖尿病视网膜病变呈显著正相关的关系(r=0.788)。结论糖尿病视网膜病变是糖尿病患侧常见并发症,血糖水平、血脂水平是其发生的影响因素,而病程与糖尿病视网膜病变以及严重程度呈正相关的关系。
Objective To investigate the relationship between the course of diabetes and diabetic retinopathy.Methods A total of 150 patients with type 2 diabetes diagnosed and treated in the hospital from January to June 2018 were selected as subjects.The patients were divided into NDR group,NPDR group and PDR group according to whether the patient had diabetic retinopathy.The general and clinical data of patients were recorded,including age,gender,BMI,smoking,fasting blood glucose(FBG),postprandial 2h blood glucose(2hPG),glycosylated hemoglobin(HbA1c),the course of diabetes and blood lipid levels(TG,TC,HDL-C,LDL-C)level.The diabetic retinopathy was analyzed and the association between the course of diabetes and diabetic retinopathy was analyzed.Results(1)There were patients with DR in 150 cases,and the incidence rate was 54.67%.Among them,63 cases were NPDR,accounting for 76.83%,and 19 cases were PDR,accounting for 23.17%.(2)The levels of FBG,2hPG,HbA1c,TC,TG and LDL-C in PDR group were the highest,and the level of HDL-C was the lowest,followed by that in NPDR group.The difference among the three groups was statistically significant(P<0.05).The PDR group had the longest course of disease,followed by the NPDR group,and the NDR group had the shortest course,and the difference was statistically significant(P<0.05).(3)Multivariate analysis showed that duration of diabetes,FBG,2hPG,TC,TG,LDL-C were independent risk factors for diabetic retinopathy(P<0.05),and HDL-C was a protective factor(P<0.05).(4)The course of disease was significantly positively correlated with diabetic retinopathy(r=0.788).Conclusion Diabetic retinopathy is a common complication of diabetic patients.Blood glucose level and blood lipid level are the influencing factors,and the course of disease is positively correlated with diabetic retinopathy and severity.
作者
陈晨
吴双庆
王玉芳
郑丽娟
CHEN Chen;WU Shuangqing;WANG Yufang;ZHENG Lijuan(Department of Ophthalmology,Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Hangzhou Red Cross Hospital,Hangzhou 310003,China)
出处
《中国现代医生》
2020年第11期77-80,共4页
China Modern Doctor
基金
浙江省中医药科技计划(2016ZA151)。
关键词
糖尿病
病程
视网膜病变
相关性
Diabetes
Disease course
Retinopathy
Correlation
