摘要
目的分析恶性肿瘤合并静脉血栓栓塞症(VTE)患者的临床特点并探寻相关危险因素。方法采用回顾性病例对照研究,调查恶性肿瘤合并VTE患者的临床及生存结局信息。采用卡方检验、Log rank检验和比例风险回归模型(Cox模型)等方法进行统计分析,采用GraphPad Prism8.0绘制生存曲线,分析VTE相关影响因素。结果5年间共收治新发恶性肿瘤患者11620例,其中合并VTE患者385例(3.31%)。恶性淋巴瘤患者合并VTE的比例最大,达到4.78%,其次是结直肠癌和乳腺癌,分别为4.40%和4.08%;联合治疗的患者比单一治疗方式发生VTE的比例高;分期越晚的患者合并VTE的比例越高;随访结果显示合并VTE患者中位生存时间为17.90月(95%CI:10.21~25.59),1、3、5年生存率分别为51.89%、37.76%、18.88%;多因素分析结果显示年龄、性别、TNM分期是影响VTE患者预后的独立危险因素。结论恶性肿瘤患者容易并发VTE,临床上应对高危患者密切观察、提早预防。
Objective To investigate the clinical features of cancer patients with venous thromboembolism(VTE)and related risk factors.Methods A retrospective case-control study was conducted to investigate the clinical and survival outcomes of cancer patients with VTE.Statistical analysis of VTE-related influencing factors was performed using chi-square test,Log rank test and proportional hazard regression model(Cox model).GraphPad Prism8.0 was used to draw the survival curve.Results We collected 11620 patients with new-onset cancer,including 385 patients with VTE.The incidence of VTE in cancer patients was 3.31%.The incidence of VTE in malignant lymphoma patients was the highest(4.78%),followed by colorectal cancer(4.40%)and breast cancer(4.08%).Patients treated with combination therapy had a higher rate of VTE.TNM staging was positively correlated with the proportion of VTE in cancer patients.The median survival time was 17.90 months(95%CI:10.21-25.59),and the 1-,3-and 5-year survival rates were 51.89%,37.76%and 18.88%,respectively.Multivariate analysis results showed that age,gender and TNM staging were independent risk factors affecting the survival and prognosis of patients.Conclusion Patients with malignant tumors are prone to VTE.High-risk patients should be closely observed to prevent VTE.
作者
雷海科
李小升
龙波
李禄椿
罗敏
王璐璐
赵玉兰
周宏
刘海霞
张维
LEI Haike;LI Xiaosheng;LONG Bo;LI Luchun;LUO Min;WANG Lulu;ZHAO Yulan;ZHOU Hong;LIU Haixia;ZHANG Wei(Cancer Prevention and Control Office,Chongqing University Cancer Hospital,Chongqing 400030,China;Medical Department,Chongqing University Cancer Hospital,Chongqing 400030,China;Department of Development,Chongqing University Cancer Hospital,Chongqing 400030,China;Deanery,Chongqing University Cancer Hospital,Chongqing 400030,China)
出处
《肿瘤防治研究》
CAS
CSCD
2020年第4期256-261,共6页
Cancer Research on Prevention and Treatment
基金
重庆市卫生健康委重点疾病防治技术攻关课题(2019ZX002)
重庆市技术创新与应用发展专项(cstc2019jscx-fxydX0008)
学科交叉及团队培育专项——医工融合项目(2019CDYGYB014)。
关键词
恶性肿瘤
静脉血栓栓塞症
危险因素
预防治疗
预后
Cancer
Venous thromboembolism
Risk factors
Prevention and treatment
Prognosis
