摘要
Summary of main observation and conclusion An eficient palladium-atalyzed regioselective 5 exo aminotrifluoromethoxylation of alkenes has been established herein,which provides practical route towards the synthesis of OCF g-containing prrolidines.tert-Butyloxycarbonyl(Boc)as an amino pro-tecting group plays a signifiant role in both the chemo-and regloselectivities.In addition,preliminary mechanistic studies reveal that the amino protect-ing group of substrates and the counter anion of palladium catalyst play critical roles in reaction efficiency presumably due to an isomerization of alkyl-Pd(Ⅱ)intermediates.Moreover,the asymmetric 5-exo aminrifluoromethoxylation reaction has also been achieved by introducing a serelallyl bulky pyri-dinyl-oxazoline ligand.
基金
We are grateful for financial support from the National Natural Science Foundation of China(Nos.21532009,21761142010,21971255,21728201 and 21790330)
the Science and Technology Commission of Shanghai Municipality(Nos.17XD1404500,170A1405200 and 17JC1401200)
the strategic Priority Re-search Program(No.XDB2000000)
the Key Research Pro-gram of Frontier Science(QYZDISSW-SLH055)of the Chinese Academy of Sciences.
