摘要
目的系统分析重症新型冠状病毒肺炎(COVID-19)患者基础疾病的患病率。方法计算机检索PubMed、EMbase、中国知网(CNKI)、维普网(VIP)数据库和万方数据知识服务平台,查找与重症COVID-19患者合并基础病相关的文献,检索时限为2019年12月—2020年4月13日。由2名研究员独立完成文献筛选、数据收集并评价纳入研究的偏倚风险,采用Stata12.0软件进行Meta分析。结果共纳入40项回顾性研究,共计4261例重症COVID-19患者,均为高质量研究。Meta分析结果显示:重症COVID-19患者最常见的基础疾病是高血压[37.3%,95%CI(33.7%~41.1%)],其次为糖尿病[19.3%,95%CI(16.7%~21.9%)]、心血管疾病[15.4%,95%CI(12.9%~18.1%)];部分患者合并脑血管疾病[10.8%,95%CI(7.6%~14.5%)]、慢性阻塞性肺病(COPD)[9.5%,95%CI(7.1%~12.2%)],少数患者可伴有慢性肾病[5.5%,95%CI(3.7%~7.5%)]、恶性肿瘤[5.0%,95%CI(4.2%~5.7%)]及慢性肝病[4.5%,95%CI(3.0%~6.4%)]。结论当前证据表明,高血压、糖尿病和心脑血管疾病是重症COVID-19患者最常见的基础疾病;部分患者合并有COPD、恶性肿瘤、慢性肝病和慢性肾病。
Objective To systematically analyze the prevalence of underlying diseases in patients with severe coronavirus disease 2019(COVID-19).Methods PubMed,Embase,CNKI,VIP database,and Wanfang Data Knowledge Service Platform were electronically searched to collect studies about the prevalence of underlying diseases in severe COVID-19 patients from 1 December 2019 to 13 April 2020.Two reviewers independently screened literature,extracted data,and assessed the risk of bias of included studies,then,a meta-analysis was performed by using Stata12.0 software.Results A total of 40 retrospective studies involving 4261 severe COVID-19 patients were included.All of the studies were of high quality.Meta-analysis showed that the most common underlying disease was hypertension(37.3%,95%CI 33.7%to 41.1%),followed by diabetes(19.3%,95%CI 16.7%to 21.9%)and cardiovascular disease(15.4%,95%CI 12.9%to 18.1%).Other underlying diseases were cerebrovascular disease(10.8%,95%CI 7.6%to 14.5%),chronic obstructive pulmonary disease(COPD)(9.5%,95%CI 7.1%to 12.2%),chronic kidney disease(5.5%,95%CI 3.7%to7.5%),malignant tumors(5.0%,95%CI 4.2%to 5.7%)and chronic liver disease(4.5%,95%CI 3.0%to 6.4%).Conclusion Current evidence shows that hypertension,diabetes and cardio-cerebrovascular disease were the most common underlying diseases in severe COVID-19 patients.COPD,malignant tumors,chronic kidney disease,and chronic kidney disease were also observed in some patients.
作者
李红园
朱洁云
钟枝梅
吉攀
李柏成
庞杰龙
张剑锋
Li Hongyuan;Zhu Jieyun;Zhong Zhimei;Ji Pan;Li Bocheng;Pang Jielong;Zhang Jianfeng(Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China)
出处
《疑难病杂志》
CAS
2020年第6期541-547,共7页
Chinese Journal of Difficult and Complicated Cases
基金
国家自然科学基金(81960343)
广西重点研发计划防控新型冠状病毒感染肺炎疫情应急科技攻关专项(2020AB39028)
广西医学高层次骨干人才培养‘139’计划(G201903027)。
