摘要
细辛临床药效显著,应用广泛。目前已上市的中药成方制剂中,有40余种都含有细辛。然而,近年来细辛的“毒性”受到了医药界的普遍关注,其临床用药的安全性也遭受到质疑,这极大程度上限制了细辛良好药用价值的发挥。细辛的“有毒”与“无毒”尚具争议。基于细辛“毒性”视角,分别从呼吸毒性、肝毒性、肾毒性和遗传毒性4个方面进行整理,并对品种、配伍、炮制、用药剂量、剂型等可有效控制细辛“毒性”的方法进行总结与分析,以期为细辛的规范用药和安全用药提供科学依据。
Asari Radix et Rhizoma has remarkable clinical efficacy with wide application.Asari Radix et Rhizoma is found in more than 40 kinds of traditional Chinese medicine formulations.However,in recent years,the toxicity of Asari Radix et Rhizoma has been widely concerned by the medical community,and the safety of its clinical use has been questioned,which greatly limits the use of Asari Radix et Rhizoma as a valuable medicine.It is still controversial that whether Asari Radix et Rhizoma is toxic or not.Based on the toxic perspective of Asari Radix et Rhizoma,the toxicity of respiration,liver,kidney and heredity were sorted out,and the methods for effective control of the toxicity of Asari Radix et Rhizoma,such as variety,compatibility,processing,dosage,dosage form and so on,were summarized and analyzed,so as to provide scientific basis for the standardized and safe use of Asari Radix et Rhizoma.
作者
宗时宇
刘洋
孙婷婷
张红
王春柳
支文冰
李晔
Zong Shiyu;Liu Yang;Sun Tingting;Zhang Hong;Wang Chunliu;Zhi Wenbing;Li Ye(Shaanxi Academy of Traditional Chinese Medicine,Xi’an 710003,China)
出处
《中国药师》
CAS
2020年第5期942-945,共4页
China Pharmacist
基金
陕西省创新能力支撑计划资助(编号:2019KJXX-020)
陕西省中医药研究院-陕西省中医医院院级科研课题(编号:2018-07)。
关键词
细辛
毒性
控制方法
安全用药
Asari Radix et Rhizoma
Toxicity
Control methods
Safe medication
