摘要
原发性胆汁性胆管炎(PBC)是一种病因不明的自身免疫性胆汁淤积性肝病,肝穿刺活检是重要的诊断手段,但因其有创性,临床运用有限。自身抗体对于PBC有特殊诊断及预后价值,代表性抗体有抗线粒体抗体和抗核抗体,各抗体的临床意义不尽相同。综述了PBC相关自身抗体的诊断及预后意义及相关进展。
Primary biliary cholangitis(PBC)is an autoimmune cholestatic liver disease with unknown etiology.Liver biopsy is an important diagnostic tool,but its clinical application is limited due to its invasiveness.Autoantibodies have special diagnostic and prognostic value for PBC,especially anti-mitochondrial antibodies and antinuclear antibodies,and each antibody has unique clinical significance.This article reviews the diagnostic and prognostic significance of autoantibodies associated with PBC and related research advances.
作者
党富涛
唐映梅
DANG Futao;TANG Yingmei(Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第5期1164-1166,共3页
Journal of Clinical Hepatology
基金
国家自然科学基金项目(81360072,81660102)。
关键词
胆管炎
硬化性
自身抗体
诊断
预后
cholangitis,sclerosing
autoantibodies
diagnosis
prognosis
