摘要
目的 通过分析临床医疗大数据了解真实世界HBV感染情况和乙型肝炎(乙肝)疫苗免疫策略效果。方法筛选Suvalue数据库中自2006年1月至2017年7月有年龄、性别、HBsAg、抗-HBs、HBeAg和抗-HBc检查结果的数据(包括63家3级及2级医院)。分析总体、不同年龄段及不同性别人群HBsAg、抗-HBs、HBeAg和抗-HBc阳性率随时间变化趋势。并将HBsAg结果与2006年、2014年全国人群乙肝血清流行病学调查结果相比较。结果 共2 311 221人纳入研究,其中男性919 908人,女性1 391 313人。所研究人群的HBsAg、HBeAg及抗-HBc阳性率总体呈逐年下降趋势,分别由2006年的17.4%、7.1%、32.9%降至2017年的5.9%、2.3%、24.2%;而抗-HBs呈逐年上升趋势,由2006年的47.6%增加至2017年的56.4%。有意义的是,2006年及2014年1~4岁和5~14岁的HBsAg阳性率(分别为1.4%、9.1%和0.4%、0.9%)与同时期全国人群乙肝血清流行病学调查结果(0.96%、10.6%和0.3%、0.9%)相近(P<0.05)。结论 临床医疗大数据分析有助于了解真实世界小年龄组(<15岁)HBV感染状况,从而间接反映国家乙肝疫苗免疫规划的效果。
Objective To better understand HBV infection status and the immunity effects of hepatitis B in the National Immunization Program in real-world clinical practice.Methods Data were retrieved from the SuValue database(including 63 tertiary and secondary hospitals across China)from January 2006 to July 2017.The positive rates of surface antigen(HBsAg),hepatitis B surface antibody(anti-HBs),and hepatitis B core anti-body(anti-HBc)were analyzed and compared with the results of the national seroepidemiological survey of hepatitis B in 2006 and 2014.Results A total of 2311221 participants were included in this study,including 919908 men and 1391313 women.From 2006 to 2007,the overall positive rates of HBsAg,HBeAg and anti-HBc declined from 17.4%,7.1%,32.9%to 5.9%,2.3%,24.2%,whereas the positive rate of anti-HBs increased from 47.6%to 56.4%.Interestingly,the HBsAg positive rate in the groups of 1-4 years and 5-14 years in 2006(1.4%and 9.1%)and 2014(0.4%and 0.9%)were close to that in the national seroepidemiological survey of hepatitis B conducted in 2006(0.96%and 10.6%)and 2014(0.3%and 0.9%,P<0.05).Conclusion The big data from real-world clinical practice can be used to monitor the HBsAg positive rate and evaluate the immunity effect of hepatitis B vaccine in the National Immunization Program those younger than 15 years old.
作者
单姗
李敏
田永谦
孔媛媛
尤红
贾继东
SHAN Shan;LI Min;TIAN Yong-qian;KONG Yuan-yuan;YOU Hong;JIA Ji-dong(Liver Research Center,Beijing Friendship Hospital,Capital Medical University,National Clinical Research Center for Digestive Diseases,Beijing 100050,China;Shanghai Suvalue Health Scientific Ltd.,Shanghai 200032,China)
出处
《肝脏》
2020年第5期472-475,479,共5页
Chinese Hepatology
