摘要
目的探讨伴有双皮质综合征(double cortex syndrome,DCS)的癫痫患者的电生理及临床特征。方法回顾性分析4例伴有DCS的癫痫患者的病史、影像、电生理、发作类型及临床治疗。结果4例患者均为女性,起病年龄1~13岁,均有不同程度智力发育障碍。2例患者脑电图背景节律明显变慢,3例患者发作间期以双侧颞顶枕区癫痫样放电为主,同步或交替出现,可有侧别优势;捕获到发作的3例患者发作期均为广泛放电起源。临床发作均表现为多种发作形式,其中3例具有继发全面强直或强直-阵挛,该发作形式对药物的敏感性较好。结论伴有DCS的癫痫患者发病率有明显女性性别优势,起病年龄越早,智力发育受影响越大,癫痫样放电以双侧后头部为主,发作起源广泛,发作形式多样,抗癫痫药物对全面强直或强直-阵挛发作控制较好。
Objective To investigate the electro-clinical characteristics of epilepsy patients with double cortex syndrome(DCS).Methods We retrospectively analyzed the history,imaging,electrophysiology,seizure type and clinical treatment of 4 epilepsy patients with DCS.Results All 4 patients were female,and the onset age was 1 to 13 years old.All had different degrees of mental development disorders.The EEG background rhythm was significantly slower in 2 patients.In 3 patients,the interictal epileptic discharges were mainly located in the temporo-parieto-occipital area bilaterally,appeared synchronously or alternately,and could also be mainly distributed on one side.In 3 patients who had seizures all had a widespread seizure origin.All 4 patients had multiple seizure types,and secondary general tonic or general tonic-clonic can be well controlled in 3 patients.Conclusion The incidence of epilepsy patients with DCS has obvious female gender advantage,and the earlier the onset age,the greater the impact on intellectual development.Interictal epileptic discharges in these patients were mainly located on posterior head bilaterally.Furthermore,it has the characteristics of wide distributed seizure onset zone,various seizure types,and well controlled seizure type of general tonic or general tonic-clonic by antiepileptic drugs.
作者
李焕发
孟强
董珊
张华
LI Huanfa;MENG Qiang;DONG Shan(Department of Neurosurgery,The First Affiliated Hospital of Xi’an JiaoTong University,Xi’an 710061,China)
出处
《中风与神经疾病杂志》
CAS
2020年第5期441-444,共4页
Journal of Apoplexy and Nervous Diseases
关键词
癫痫
双皮质综合征
电生理
发作
Epilepsy
Double cortex syndrome
Electrophysiology
Seizure
