摘要
目的研究小儿癫痫给予左乙拉西坦治疗的效果及对炎症因子血清白介素6(interleukin-6,IL-6)、血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)及Toll样受体4(TLR4)、核因子(NF-kB)水平的影响作用。方法以商丘市第三人民医院2015-04—2019-04收治的103例小儿癫痫为对象,按照随机数字表法分为2组,对照组51例接受卡马西平治疗,观察组52例患儿接受左乙拉西坦治疗,比较2组治疗总有效率、TLR4/NF-kB水平变化、炎症因子水平变化、认知功能。结果观察组治疗总有效率为94.23%高于对照组的78.43%(P<0.05);观察组治疗后TLR4、NF-kB水平均低于对照组(P<0.05);观察组治疗后炎症因子IL-6、TNF-α、hs-CRP水平均低于对照组(P<0.05)。结论左乙拉西坦治疗小儿癫痫具有良好临床疗效,能够更明显控制TLR4/NF-kB水平,减轻炎症反应,具有良好应用价值。
Objective To study the therapeutic effect of levetiracetam on pediatric epilepsy and the improvement of IL-6,TNF-a,hs-CRP levels,TLR4/NF-kB.Methods From April 2015 to April 2019 treated 103 cases of infantile epilepsy as object,according to random number table method is divided into two groups,control group 51 cases treated with carbamazepine,observation group 52 cases underwent left braschig treatment,compared two groups total effective treatment,TLR4/NF-kB level changes and inflammatory factor levels and cognitive function.Results The total effective rate in the observation group was 94.23%,higher than that in the control group(78.43%)(P<0.05).TLR4 and nf-kb levels in the observation group were lower than those in the control group(P<0.05).The levels of inflammatory cytokines IL-6,TNF-αand hs-CRP in the observation group were lower than those in the control group(P<0.05).Conclusion Levetiracetam has good clinical efficacy in the treatment of epilepsy in children.It can control the level of TLR4/NF-kB more obviously and reduce the inflammatory response.It has good application value.
作者
陈玉霞
CHEN Yuxia(Third People's Hospital of Shangqiu,Shangqiu 476000,China)
出处
《中国实用神经疾病杂志》
2020年第8期682-686,共5页
Chinese Journal of Practical Nervous Diseases
