摘要
目的探讨早期肠内营养对急性脑梗死患者肠道菌群结构及营养状态的影响。方法对2018年3月-2019年6月收治的112例急性脑梗死患者的临床资料进行回顾:均接受常规治疗,有51例未予以早期肠内营养支持,纳入A组;余61例接受早期肠内营养支持治疗,纳入B组。对比治疗前后两组肠道菌群结构变化、营养状态、胃肠道并发症发生率和预后不良发生率。结果治疗后A组肠道菌群Chao1指数、Shannon指数、Bacteroides、Lactobacillus、Bifidobacterium、Faecalibacterium、Enterococcus、Parabacteroides属水平相对丰度均较治疗前下降(均P<0.05),B组治疗后各项与治疗前比较差异均无统计学意义(均P>0.05),且B组均高于A组(均P<0.05);治疗后A组Candida、Escherichia、Streptococcus属水平相对丰度均较治疗前升高(均P<0.05),B组治疗后各项与治疗前相比差异均无统计学意义(均P>0.05),且治疗后B组均低于A组(均P<0.05)。治疗前两组血清SAB、TRF、TSF相比差异均无统计学意义(均P>0.05),治疗后A组各指标均较治疗前下降(均P<0.05),B组治疗后与治疗前相比差异均无统计学意义(均P>0.05);治疗后两组营养状态指标比较,B组血清SAB、TRF、TSF均高于A组(均P<0.05)。B组胃肠道并发症发生率、不良反应发生率均低于A组(均P<0.05)。结论对急性脑梗死患者予以早期肠内营养可改善其肠道菌群结构、营养状态,降低胃肠道并发症和预后不良发生率。
Objective To explore the effect of early enteral nutrition on intestinal microbiota and nutritional status in patients with acute cerebral infarction.Methods The clinical data of 112patients with acute cerebral infarction treated from March 2018to June 2019were retrospectively analyzed.All patients received conventional treatment.Fifty-one patients without early enteral nutrition support were described as group A.The remaining 61cases received early enteral nutrition support treatment were described as group B.The intestinal microecological structure and complexity were compared between the two groups before and after treatment.Nutritional status was compared.The incidence of gastrointestinal complications with the incidence of poor prognosis was compared.Results The Chao1index and Shannon index of intestinal microecology,and relative abundance of Bacteroides,Lactobacillus,Bifidobacterium,Faecalibacterium,Enterococcus and Parabacteroides at genus levels in group A decreased after treatment(all P<0.05).There were no significant differences in group B before and after treatment(all P>0.05),and the indexes in group B were higher than those in group A after treatment(all P<0.05).The relative abundance of Candida,Escherichiaand Streptococcus at genus levels in group A increased after treatment(all P<0.05);there were no significant differences in group B before and after treatment(all P>0.05),and the indexes in group B were lower than those in group A after treatment(all P<0.05).There were no significant differences in the levels of serum SAB,TRF and TSF between the two groups before treatment(all P>0.05),which decreased in group A after treatment(all P<0.05),and there were no significant differences in group B before and after treatment(all P>0.05).After treatment,the levels of serum SAB,TRF and TSF in group B were higher than those in group A(all P<0.05).The incidences of total gastrointestinal complications and poor prognosis in group B were lower than those in group A(all P<0.05).Conclusion Early enteral nutrition in patients with acute cerebral infarction can improve the intestinal microbiota and nutritional status,and reduce the incidences of gastrointestinal complications and poor prognosis.
作者
焦美芝
马红岗
陆斌
JIAO Meizhi;MA Honggang;LU Bin(Neurology,Zhebei Mingzhou Hospital,Huzhou,Zhejiang 313000,China)
出处
《中国微生态学杂志》
CAS
CSCD
2020年第4期451-454,464,共5页
Chinese Journal of Microecology
关键词
早期肠内营养
急性脑梗死
肠道菌群
Early enteral nutrition
Acute cerebral infarction
Intestinal microbiota
