摘要
卵泡刺激素(FSH)刺激颗粒细胞增殖并控制卵泡的发育和成熟。本研究中采用白色獭兔品系的70只母兔和海狸色獭兔品系的100只母兔,研究了FSHβ的SNPs与繁殖性状间的关系。发现在FSHβ基因外显子1和外显子3中的3个SNPs(FSH2,FSH30,FSH31)在联合群体中与繁殖性状具有强相关。对于FSH2,与TT基因型相比,GG基因型与总产仔数(TNB)和产活仔数(NBA)相关联较高(P <0.05)。对于FSH30,AA基因型的总产仔数(TNB)和产活仔数(NBA)显著高于GG基因型和AG基因型(P <0.05)。对于FSH31,GG基因型与总产仔数(TNB),初生窝重(LWB)和21日龄活仔数(LS21)的相关性显著高于AG基因型(P <0.05),产活仔数(NBA)极显著高于AG基因型个体(P <0.01)。结果表明:FSHβ基因与獭兔的繁殖性状相关联,因此,FSH2,FSH30和FSH31可作为分子标记对獭兔进行选育。
Follicle-stimulating hormone(FSH) stimulate granulosa cell proliferation and controls the developmentand maturation of oocytes. In this study with Rex rabbit, there was exploration of the relationships between reproduc-tive traits and SNPs of FSHβ, using 70 females from the White line and 100 females from the Beaver line. ThreeSNPs(FSH2, FSH30, FSH31) in exon1 and exon3, of FSHβ were strongly associated with reproductive traits in thecombined population. For FSH2, the GG variant were associated with greater(P < 0.05) values for total number born(TNB) and number born alive(NBA), compared to those with the TT variant. For FSH 30, for the AA variant therewas greater(P < 0.05) values for TNB and NBA than the GG and AG variants. For FSH31, the GG variant was associ-ated with greater(P < 0.05) values for TNB, litter weight at birth(LWB) and litter size at 21 days of age(LS21), thanthe AG variant, and with the greater(P < 0.01) values for NBA than the AG variant. It is concluded that genetic varia-tion in FSHβ gene is associated with reproductive traits in the Rex rabbit, therefore, the FSH2, FSH30 and FSH31 SNPs can be used as molecular markers in genetic selection of rabbits.
作者
牛晓艳
曹亮
李燕平
郑建婷
冯国亮
詹海杰
唐耀平
刘文忠
任克良
Niu Xiao-yan;Cao Liang;Li Yan-ping;Zheng Jian-ting;Feng Guo-liang;Zhan Hai-jie;Tang Yao-ping;Liu Wen-zhong;Ren Ke-liang(Sciences of ShanXi Agricultural Academy Institute of Animal Husbandry and Veterinary,Taiyuan 030032;College of Animal Science and Veterinary Medicine Shanxi Agricultural University,Taigu 030801)
出处
《中国养兔》
2020年第1期4-7,16,共5页
Chinese Journal of Rabbit Farming
基金
国家兔产业技术体系专项资金资助(CARS-43-B-3)
山西省农业科学院博士基金项目(YBSJJ1401)。
关键词
獭兔
卵泡刺激素
繁殖
关联性
Rex rabbit
Follicle-stimulating hormone
Reproduction
Association
