摘要
肺炎克雷伯杆菌是感染性疾病的常见致病菌,其所致的侵袭性肝脓肿以及转移性感染,称为侵袭性肝脓肿综合征。近年该类报道明显增多,地理范围从台湾、亚洲、南非蔓延至全球,亚洲人或亚裔更具易感性。糖尿病似乎是侵袭性综合征的危险因素之一。高黏稠性提示菌株高毒力,与荚膜血清分型、magA、rmpA及气杆菌素呈相关性。快速识别高毒力菌株、尽早应用敏感抗生素及充分引流可明显减少后遗症并改善患者预后。该文就该综合征流行病学、毒力因素、临床表现及治疗等方面进行现状分析。
Klebsiella pneumoniae is a common pathogen of infectious diseases. The invasive liver abscess and metastatic infection caused by it are called invasive liver abscess syndrome. In recent years, such reports have increased significantly, and the geographic scope has spread from Taiwan, Asia, and South Africa to the world, and Asians or Asian descents are more susceptible. Diabetes appears to be a risk factor for invasive syndrome. High viscosity indicates high virulence of the strain, which is related to capsular serotyping, magA, rmpA, and aerobicin.Rapid identification of highly virulent strains, early application of sensitive antibiotics, and adequate drainage can significantly reduce sequelae and improve patient prognosis. This article analyzes the status quo of epidemiology,virulence factors, clinical manifestations and treatment of the syndrome.
作者
刘芳
朱华栋
LIU Fang;ZHU Hua-dong(Chinese Academy of Medical Sciences/Peking Union Medical College/Peking Union Medical College Hospital,Beijing,100730 China)
出处
《系统医学》
2020年第5期190-192,共3页
Systems Medicine
关键词
肺炎克雷伯杆菌
侵袭性肝脓肿
高黏稠性表型
眼内炎
Klebsiella pneumoniae
Invasive liver abscess
Highly viscous phenotype
Endophthalmitis
