摘要
目的食管癌是常见的消化道恶性肿瘤,山东省肥城市是我国食管癌高发地区之一。探讨山东省肥城市农村居民食管癌及癌前病变发生的危险因素,为当地食管癌的防治工作提供依据。方法以2013年在"国家食管癌早诊早治示范基地(山东省肥城市)"参与上消化道癌症筛查,并进入食管癌筛查与随访社区人群队列的40~69岁农村居民为研究对象,内镜下碘染色及病理活检结果作为诊断依据,依据诊断标准将其分为不同病变等级,进行问卷调查,并采用多元有序Logistic回归分析食管癌及癌前病变的危险因素。结果共纳入食管正常人1910名、轻度增生511例、中度增生130例、重度增生及以上100例。多元有序Logistic回归分析结果显示,年龄(OR=1.09,95%CI:1.08~1.11)、饮酒(OR=1.45,95%CI:1.13~1.86)、饮茶(OR=1.39,95%CI:1.15~1.68)、燃煤取暖(OR=1.43,95%CI:1.10~1.85)及肿瘤家族史(OR=1.35,95%CI:1.11~1.66)是食管癌及癌前病变发生的独立危险因素,P<0.05。结论年龄、饮酒、饮茶、燃煤取暖及肿瘤家族史是肥城市农村居民食管癌及癌前病变的危险因素,改变不良生活方式有利于做好食管癌的防治工作。
OBJECTIVE Esophageal cancer is a common malignant tumor of digestive tract.Feicheng,Shandong Province is one of the areas with high incidence of esophageal cancer in China.This study aimed to explore the risk factors of esophageal cancer and precancerous lesions in Feicheng rural areas to provide the basis for preventing esophageal cancer.METHODS In this study,rural residents aged 40 to 69 years who participated in upper gastrointestinal cancer screening in 2013 at"national esophageal cancer early diagnosis and early treatment demonstration base(Feicheng,Shandong province)"and were enrolled in the community population cohort of esophageal cancer screening and follow-up were selected as subjects.Iodine staining under the endoscope and pathological biopsy results were taken as the diagnostic basis,and pathology results were classified into different grades according to the diagnostic criteria.Then questionnaire survey was conducted,and multivariate ordinal logistic regression analysis was used to analyze the risk factors of esophageal cancer and precancerous lesions.RESULTS This study included 1910 cases of normal esophagus,511 cases of mild hyperplasia,130 cases of moderate hyperplasia and 100 cases of severe hyperplasia or above.The multivariate ordinal logistic regression analysis showed that age(OR=1.09,95%CI:1.08-1.11),alcohol drinking(OR=1.45,95%CI:1.13-1.86),tea drinking(OR=1.39,95%CI:1.15-1.68),coal-fired heating(OR=1.43,95%CI:1.10-1.85)and family history of cancer(OR=1.35,95%CI:1.11-1.66)were the independent risk factors for the esophageal cancer and precancerous lesions,P<0.05.CONCLUSION Age,alcohol drinking,tea drinking,coal-fired heating and family history of cancer are risk factors of esophageal cancer and precancerous lesions in the rural residents of Feicheng,and changing unhealthy lifestyle is beneficial to the prevention of esophageal cancer.
作者
李霞
赵莉
史思达
杨佳
张楠
王家林
LI Xia;ZHAO Li;SHI Si-da;YANG Jia;ZHANG Nan;WANG Jia-lin(Department of Biostatistics,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,P.R.China;Institute for Medical Datology,Shandong University,Jinan 250002,P.R.China;Department of Cancer Center,People's Hospital of Feicheng,Feicheng 271600.P.R.China;De partment of Education and Cancer Prevenion,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250117.P.R.China;Schoo of Medicine and Life Sciences,Shandong Academy of Medical Sciences.University of Jinan,Jinan 250022,P.R.China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2020年第7期499-504,共6页
Chinese Journal of Cancer Prevention and Treatment
基金
国家重点研发计划(2016YFC1302800,2016YFC0901400)
国家自然科学基金(81573246,71904109)
山东省科技发展计划(2017GSF18101)
山东省自然科学基金(ZR2019PG006)。
关键词
食管癌
癌前病变
危险因素
多元有序Logistic回归分析
肥城
esophageal cancer
precancerous lesions
risk factors
multivariate ordinal logistic regression analysis
Feicheng
