摘要
目的了解在重庆梁平地区13C呼气试验阳性的患者中分离的幽门螺杆菌对6种抗生素(克拉霉素、阿莫西林、左氧氟沙星、四环素、甲硝唑、呋喃唑酮)的耐药情况,掌握本地区幽门螺杆菌对常用抗生素的药敏谱。方法选择2018年11月到2019年3月在该院行13C-尿素酶呼气试验检查(13C-UBT)且结果为Hp阳性的就诊者为研究对象。在胃镜下分别取胃窦、胃体黏膜组织各1块送杭州致远医学检验所经培养鉴定后获得菌株,并对6种常用抗生素(克拉霉素、阿莫西林、左氧氟沙星、四环素、甲硝唑、呋喃唑酮)进行药敏试验。结果在150例胃黏膜组织标本中共分离出94例Hp菌株,对克拉霉素耐药率26.60%,甲硝唑耐药率96.81%,左氧氟沙星耐药率39.36%,未发现对阿莫西林、呋喃唑酮、四环素耐药。对1种抗生素耐药的共有39例,占总菌株的41.49%;对2种抗生素耐药的共有45例,占总菌株的47.87%;对3种抗生素耐药的共有7例,占总菌株的7.45%。其中对克拉霉素和甲硝唑双重耐药共25例,占26.60%,大于15.00%。结论重庆梁平地区对甲硝唑高度耐药,对克拉霉素、左氧氟沙星耐药率也较高,且存在双重、多重耐药情况,但尚未发现对呋喃唑酮、阿莫西林、四环素耐药。
Objective To know about the resistance of Helicobacter pylori to 6 antibiotics(clarithromycin,amoxicillin,levofloxacin,tetracycline,metronidazole,furazolidone)and master the susceptibility spectrum of helicobacter pylori to common antibiotics in Liangping area.Methods Patients who were Hp-positive detected by the 13C-urea breath test from November 2018 to March 2019 in Liangping People′s Hospital were selected as research objects.Their gastric antrum and gastric mucosal specimens were taken separately under the gastroscope and sent to Hangzhou Zhiyuan Medical Laboratory for cultivation.Through identification,bacterial strains were obtained,and drug susceptibility tests were conducted on 6 common antibiotics(clarithromycin,amoxicillin,levofloxacin,tetracycline,metronidazole,furazolidone).Results In 150 gastric mucosal tissue specimens,94 cases of Hp were detected and the resistance rate to clarithromycin,metronidazole and levofloxacin were 26.60%,96.81%and 39.36%,respectively.In addition,the resistance to amoxicillin,furazolidone or tetracycline was not found.A total of 39 cases were resistant to one antibiotic,accounting for 41.49%of the total strains;a total of 45 cases(47.87%)were resistant to 2 antibiotics and 7 cases(7.45%)were resistant to 3 antibiotics.Besides,25 cases were resistant to clarithromycin and metronidazole in the same time,accounting for 26.60%.which is more than 15.00%.Conclusion The resistance to metronidazole,clarithromycin and levofloxacin were high in Liangping area,and there were dual and multiple drug resistance,but no resistance to furazolidone,amoxicillin and tetracycline were found.
作者
周海川
卢红梅
徐畅
ZHOU Haichuan;LU Hongmei;XU Chang(Department of Gastroenterology,Liangping People's Hospital,Chongqing 405200,China)
出处
《重庆医学》
CAS
2020年第10期1657-1659,共3页
Chongqing medicine
基金
重庆市卫生和计划生育委员会科研计划项目(2016MSXM184)。
关键词
幽门螺杆菌
梁平地区
抗生素耐药
Helicobacter pylori
Liangping area
antibiotic resistance
