摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种进行性的神经退行性疾病,病理生理学机制复杂,随着研究的深入,对疾病的表观研究也从宏观深入到分子水平。有关AD的诊断,除可根据患者日常生活中行为、性格改变外,还可借助CT、MRI、PET、脑电图等影像辅助检查发现其大脑结构及功能的变化,并可通过有创检查观察患者脑脊液、血液中某些生物分子和基因改变情况。本文就AD诊断的研究进展作一综述。
Alzheimer’s disease is a progressive neurodegenerative disease with complex pathophysiological mechanisms.The research on disease apparent has also been extended from the macro level to the molecular level.Its diagnosis relies on the brain structure/function findings on CT,MRI,PET and EEG,as well as the molecular and genetic changes in the cerebrospinal fluid by traumatic examinations,besides the changes of the patients’behaviors and personalities.This paper reviews the research progress of the diagnosis of Alzheimer’s disease.
作者
侯伟丽
马兰
HOU Weili;MA Lan(Department of Geriatrics,the Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《中华实用诊断与治疗杂志》
2020年第4期417-419,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
黑龙江省自然科学基金(重点项目)(ZD2018017)。
