摘要
缺血性心脏病具有高发病率和高死亡率的特点,严重危害人们身体健康。线粒体自噬能选择性清除受损的细胞器,对维持心肌细胞内稳态和保护缺血心肌具有重要意义。越来越多的研究发现,中医药可以通过调节线粒体功能和自噬来改善心肌细胞的缺血性损伤。以线粒体作为中医药在心肌细胞内的作用靶点去探索治疗缺血性心脏病的有效措施,已成为相关中医药工作者研究的热点。基于上述背景,本文概述了线粒体自噬的主要调控途径,并综述相关益气活血类中药与线粒体自噬在该领域的研究。
Objective Abstract Ischemic heart disease has been featured by high morbidity and high mortality,which seriously endangers people's health.Mitophagy can selectively remove damaged organelles,and has a role in maintaining the homeostasis of myocardial cells and protecting ischemic myocardium.More and more studies have found that traditional Chinese medicine can improve ischemic damage of cardiomyocytes by regulating mitochondrial function and autophagy.Using mitochondria as the target of traditional Chinese medicine in cardiomyocytes to explore the treatment of ischemic,effective measures for heart disease have become a hotspot for related Chinese medicine workers.Based on the above background,this article outlines the main regulatory pathways of mitochondrial autophagy,and reviews of researches on traditional Chinese medicine of benefiting Qi and activating blood and mitophagy in this field.
作者
何业辉
卢健棋
HE Ye-hui;LU Jian-qi(Guangxi University of Chinese Medicine, Nanning 530200, China;The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China)
出处
《海南医学院学报》
CAS
2020年第10期791-795,共5页
Journal of Hainan Medical University
基金
国家自然科学基金项目(81673891)。
关键词
中医药
益气活血
线粒体自噬
缺血性心脏病
Traditional Chinese medicine
Benefiting Qi and activating blood
Mitophagy
Ischemic heart disease
