摘要
【目的】观察扶正复方颗粒对化疗所致白细胞减少症的临床疗效及后续化疗接受率的影响。【方法】将100例进行术后化疗的恶性肿瘤患者随机分为治疗组和对照组,每组各50例。对照组给予重组人粒细胞集落刺激因子(rhG-CSF)治疗,治疗组在对照组的基础上给予扶正复方颗粒口服治疗,2组均给予连续治疗2个周期,每个周期为21 d。检测2组患者化疗前及化疗后7 d、14 d、21 d外周血白细胞计数(WBC)及中性粒细胞(NEUT)计数水平,观察2组患者治疗前后中医证候评分和生活质量Karnofsky评分(KPS)变化情况,评估2组患者临床疗效及后续化疗接受率。【结果】(1)疗效方面,治疗2个周期后,治疗组的总有效率为94.0%(47/50),对照组为76.0%(38/50),治疗组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)外周血WBC及NEUT方面,化疗后7 d,2组患者的WBC和NEUT均较化疗前明显下降(P<0.05),但治疗组的下降幅度均低于对照组(P<0.05);化疗后14 d和21 d后,2组患者的WBC和NEUT均较前1个观察时点明显升高(P<0.05),且治疗组的升高作用均明显优于对照组(P<0.05),并均基本恢复至化疗前水平(P>0.05),而对照组的WBC和NEUT仍低于化疗前水平(P<0.05)。(3)治疗后,2组患者的中医证候评分均较治疗前明显下降(P<0.01),KPS评分均较治疗前明显升高(P<0.01),且治疗组对中医证候评分的下降作用和对KPS评分的升高作用均明显优于对照组(P<0.01)。(4)治疗组的后续化疗接受率为98.0%(49/50),对照组为96.0%(48/50),差异无统计学意义(P>0.05)。【结论】扶正复方颗粒治疗恶性肿瘤化疗后白细胞减少症疗效确切,可有效保护患者骨髓造血功能,升高外周血白细胞水平,改善患者临床症状,提高患者生活质量。
Objective To observe the clinical effect of Compound Fuzheng Granules for the treatment of leukopenia caused by chemotherapy and to explore the influence of the granules on the acceptance rate of subsequent chemotherapy.Methods A total of 100 postoperative patients with malignant tumors during the period of chemotherapy were randomly divided into treatment group and control group,50 cases in each group.The control group was given subcutaneous injection of recombinant human granulocyte-colony stimulating factor(rhG-CSF),and the treatment group was given subcutaneous injection of rhG-CSF combined with oral use of Compound Fuzheng Granules.The treatment for the two groups covered 2 continuous cycles,and 21 days constituted one cycle.Before chemotherapy,and 7,14,21 days after chemotherapy,the changes in the levels of peripheral white blood cell(WBC)count and neutrophil(NEUT)count,the scores of traditional Chinese medicine(TCM)syndrome,and the scores of quality of life of Karnofsky Performance Scale(KPS)were observed.And after treatment,the clinical efficacy and the acceptance rate of subsequent chemotherapy were evaluated in the two groups.Results(1)After treatment for two cycles,the total effective rate of the patients in the treatment group was94.0%,and that in the control group was 76.0%.The clinical effect of the treatment group was significantly stronger than that of the control group,and the difference was statistically significant(P<0.05).(2)Seven days after chemotherapy,the peripheral WBC and NEUT levels in the two groups were obviously decreased as compared with those before chemotherapy(P<0.05),and the descend in the treatment group was milder than that in the control group(P<0.05).In comparison with the levels 7 days after chemotherapy,the peripheral WBC and NEUT levels in the two groups 14 and 21 days after chemotherapy were obviously increased(P<0.05),and the ascend in the treatment group was superior to that in the control group(P<0.05).The peripheral WBC and NEUT levels in the treatment group 14 and 21 days after chemotherapy arrived to pre-chemotherapy levels(P>0.05),but the levels in the control group were lower than the pre-chemotherapy levels(P<0.05).(3)After treatment,the TCM syndrome scores were lowered and the KPS scores were increased in the two groups as compared with those before treatment(P<0.01),and the treatment group had stronger effect on decreasing TCM syndrome scores and on increasing the KPS scores than the control group(P<0.01).(4)The acceptance rate of subsequent chemotherapy in the treatment group was 98.0%and that in the control group was 96.0%,the difference between the two groups being insignificant(P>0.05).Conclusion Compound Fuzheng Granules exert certain therapeutic effect in the treatment of post-chemotherapy leukopenia in malignant tumor patients,and the granules are effective on preventing the hematopoietic function of bone marrow,increasing the white blood cell count,relieving the clinical symptoms and improving the quality of life of the patients.
作者
邢秀玲
赵海鹰
田菲
王巍
李丽君
孙映雪
刘伟然
王海燕
杜美容
XING Xiu-Ling;ZHAO Hai-Ying;TIAN Fei;WANG Wei;LI Li-Jun;SUN Ying-Xue;LIU Wei-Ran;WANG Hai-Yan;DU Mei-Rong(Tangshan Maternal and Child Health Hospital,Tangshan 063000 Hebei,China;No.982 Hospital of Chinese People’s Liberation Army,Tangshan 063004 Hebei,China;The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300192,China)
出处
《广州中医药大学学报》
CAS
2020年第5期860-865,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
河北省中医药管理局科研基金资助项目(编号:2019235)。
关键词
扶正复方颗粒
恶性肿瘤
化疗所致白细胞减少症
后续化疗接受率
生活质量
Compound Fuzheng Granules
malignant tumors
leukopenia caused by chemotherapy
acceptance rate of subsequent chemotherapy
quality of life
