摘要
恶性淋巴瘤是淋巴细胞恶变形成的恶性肿瘤,是世界上流行较广的血液系统恶性肿瘤,其发病率和死亡率一直呈上升趋势。本文综述了近年来靶向淋巴细胞分化抗原单抗,嵌合抗原受体T细胞(chimeric antigen receptor T-cell,CAR-T)和免疫检查点阻断剂等多种免疫治疗方法在胃淋巴瘤治疗中的研究进展。
Lymphoma is a worldwide lymphocyte derived hematological malignant tumor.Its morbidity and mortality has been on the rise.In this review,we summarized the most recent advances and main studies on immunotherapy in patients with primary gastric lymphoma,including monoclinal antibody of cluster of differentiation targeting lymphocyte,chimeric antigen receptor T-cell(CAR-T)and immune checkpoint inhibitors(such as PD-L1 monoclinal antibody).
作者
王亮
王进峰
李亚军
左朝晖
Wang Liang;Wang Jinfeng;Li Yajun;Zuo Chaohui(Graduates School,University of South China,Hengyang 421001,Hunan,China;Department of Gastroduodenal and Pancreatic Surgery,Affiliated Cancer Hospital of Xiangya Medical School,Central South University&Hunan Province Cancer Hospital,Hunan Province Key Laboratory of Virology(Tumor immunity),Changsha 410013,Hunan,China;Translational Medicine Research Center of Liver Cancer,Laboratory of Digestive Oncology,Hunan Province Cancer Hospital(Hunan Province Cancer Institute),Changsha 410013,Hunan,China)
出处
《消化肿瘤杂志（电子版）》
2020年第1期12-16,共5页
Journal of Digestive Oncology(Electronic Version)
基金
2017年湖南省科技厅重点研发计划项目(2017k2130)。
