摘要
发展了一种过氧化物诱导的2-芳基苯并咪唑衍生物,在温和条件下经历自由基环化反应,一步合成了系列骨架多样性的苯并咪唑并异喹啉酮化合物的新方法.该反应具有底物范围宽泛、官能团兼容性好、步骤经济等特点.机理研究表明该反应经历了碳中心自由基历程.
In this paper,a new peroxide-induced carbon-centered radical relay carbocyclization reaction with 2-arylbenzoimidazoles is described.This method provides an efficient route to a series of structurally diverse benzimidazole[2,1-a]isoquinolines under mild conditions in a straightforward manner.The reaction is compatible with a wide substrate scope,excellent functional group tolerance and high step economy.Mechanistic studies suggest that the reaction proceeds through a carbon-centered radical pathway.
作者
王薪
李国锋
孙凯
张冰
WangXin;Li Guofeng;Sun Kai;Zhang Bing(School of Chemical Engineering,Zhengzhou University,Zhengzhou 450001;College of Chemistry and Chemical Engineering,Anyang Normal University,Anyang 455000;School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第4期913-921,共9页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21801007)
河南省高校科技创新团队(Nos.18IRTSTHN004,18HASTIT006)资助项目.
关键词
自由基
碳环化
多环化合物
咪唑并异喹啉酮
radical
carbocyclization
polycyclic compounds
benzimidazole[2
1-a]isoquinolines
