摘要
目的 分析不同走油程度苦杏仁“电子鼻”气味与止咳药效的相关性.方法 运用电子鼻建立苦杏仁气味的数字化检测方法,采用小鼠氨水引咳法对不同走油程度苦杏仁止咳药效进行评价,最后基于SAS分析平台,开展苦杏仁气味的数字化测量值与止咳药效的相关性分析.结果 未走油、轻微走油的炒品、燀品与空白对照组比较,均具有显著地止咳作用;完全走油的炒品具有止咳作用,但完全走油的燀品已不具有止咳作用.电子鼻中传感器S2、S3、S4、S5、S6、S9、S10的响应值和苦杏仁止咳作用之间存在显著相关,传感器S2、S3、S4、S5、S6响应值越大,传感器S9、S10响应值越小,药材的感官气味越重,苦杏仁止咳效果越差.结论 通过气味数字化信息推断苦杏仁止咳作用的变化趋势,气味测量可用于苦杏仁的质量评价.
AIM To analyze the correlation on digitalized odor via electronic nose and cough relieving effect of Armeniacae Amarum Semen.METHODS The digitalized odor characteristics of Armeniacae Semen Amarum were measured by electronic nose.Meanwhile,the antitussive effects of Armeniacae Semen Amarum in varying degrees of rancidity were evaluated by inducing cough in the mice with ammonia water.Finally SAS analysis platform was in troduced to analyze the correlation between the antitussive effect and the digitalized odor measurement values of Ar meniacae Semen Amarum.RESULTS Compared with the blank control group,stir frying and blanching products in none and slightly deterioration had significant antitussive effect,while those stir frying products in completely deterioration had antitussive effect.On the contrary,those in completely deterioration totally had no antitussive effect.Sensors S2,S3,S4,S5,S6,S9,S10 in electronic nose all played significant roles in the relationship with antitussive effects.The response value of sensors S2,S3,S4,S5 and S6 appealing higher,S9 and S10 lower,were in agreement of the heavier sensory odor of Armeniacae Semen Amarum,directly resulting in worse antitussive effects.CONCLUSION The trend of antitussive effects of Armeniacae Semen Amarum can be inferred from digital odor information.This method can be used in quality evaluation of Armeniacae Semen Amarum.
作者
曹光昭
陈慧荣
刘玢清
姚月保
闫永红
邹慧琴
CAO Guang zhao;CHEN Hui rong;LIU Bin qing;YAO Yue bao;YAN Yong hong;ZOU Hui qin(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China;Beijing Highthink Pharmaceutical Technology Service Co.,Ltd.,Beijing 100161,China)
出处
《中成药》
CAS
CSCD
北大核心
2020年第5期1249-1254,共6页
Chinese Traditional Patent Medicine
基金
国家自然科学基金项目(81573542)。
关键词
电子鼻
苦杏仁
气味
止咳药效
相关性
electric nose
Armeniacae Semen Amarum
odor
cough relieving effect
correlation
