摘要
人类表型本体(HPO)提供了一种用于描述人类疾病表型异常的结构化、规范化、全面且定义明确的术语及其关系的表征。作为一种可计算的资源,HPO允许若干资源相互操作,旨在实现科学领域和数据库之间表型信息的复杂整合,沟通分子生物学与人类疾病之间的联系,已广泛应用于遗传病、罕见病等的研究。传统中医以取得良好的临床疗效为治疗目的,其特征性优势是个体化治疗,需要对患者进行准确的诊断、辨证,而这些都需要以获取症状为前提。因此,中医症状术语的规范化、标准化十分必要,构建以“症状”为核心的中医临床表型本体,有助于中医标准化发展,提高中医临床疗效。
Human phenotype ontology(HPO)provides a structured,standardized,comprehensive and well-defined term and its relationship characterization for describing human disease phenotype abnormality.As a computable resource,HPO allows a number of resources to interoperate,aiming at the complex integration of phenotypic information between scientific fields and databases,and communicating the link between molecular biology and human diseases.It has been widely used in genetic diseases,rare diseases and other research.Traditional Chinese medicine(TCM)takes therapeutic purpose for achieving good clinical curative effects.Its characteristic advantage is individualized treatment,which requires accurate diagnosis and syndrome differentiation of patients.All of these needs to be based on the acquisition of symptoms.Therefore,the normalization and standardization of TCM symptom terms are necessary,constructing an ontology of TCM clinical phenotype with‘symptom’as the core,which will help the development of TCM standardization and improve the clinical efficacy of TCM.
作者
孙慧娟
陈超
朱彦
马雅銮
SUN Hui-juan;CHEN Chao;ZHU Yan;MA Ya-luan(Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第3期1086-1090,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.61701546)
北京市自然科学基金项目(No.7174328)
中国中医科学院基本科研业务费自主选题项目(No.zz110318,No.zz130305)。
关键词
人类表型本体
术语
中医
标准化
症状
分子生物学
Human phenotype ontology
Term
Traditional Chinese medicine
Standardization
Symptom
Molecularbiology
