摘要
群体感应(quorum sensing,QS)是微生物中普遍存在的细胞间通讯系统,细菌中的研究较为深入,近年来在真菌中也有发现。微生物通过向环境释放可扩散的群体感应信号分子(quorum sensing molecules,QSM)来感知群体密度并调控自身的生理行为,以适应环境的变化。目前验证的真菌QSM包括醇类、脂氧合物、小分子肽以及某些挥发性物质。除影响种内的生长发育及次级代谢物产生外,真菌QSM还与其侵染能力、致病性和毒素产生有关,为了抵御QS的不利影响,生物共同进化过程中相应地出现了群体感应淬灭(quorum quenching,QQ)机制,QQ能够修饰或抑制QSM的合成从而破坏QS。本文中,笔者对国内外近10年来对真菌QSM种类、生理作用及QQ的研究进展进行综述,以期为深化真菌群体感应机制的研究提供参考。
Quorum sensing(QS)is a ubiquitous intercellular communication system in microorganisms.Microbes release diffusible quorum sensing molecules(QSM)to the environment to sense population density and regulate their own physiological behaviors to adapt to changes in the environment.Currently verified fungal QSMs include alcohols,lipoxylates,small molecule peptides,and certain volatile substances.In addition to affecting the growth and development of the species and the production of secondary metabolites,fungal QSM is also related to its infectivity,pathogenicity,and toxin production.In order to resist the adverse effects of QS,quorum induction quenching has occurred during the co-evolution of organisms.Quorum quenching(QQ)mechanism can modify or inhibit the synthesis of QSM to destroy QS.This article reviews the species,physiological effects,and QQ research progress of fungal QSM in the past 10 years at home and abroad,with a view to providing a reference for further research on fungal quorum sensing mechanisms.
作者
高婧
彭梦雪
梁志宏
GAO Jing;PENG Mengxue;LIANG Zhihong(College of Food Science& Nutritional Engineering,Beijing Advance Innovation Center for Food Nutrition and Human Health,China Agricultural University,Beijing 100083,China)
出处
《生物加工过程》
CAS
2020年第2期214-223,共10页
Chinese Journal of Bioprocess Engineering
基金
国家自然科学基金面上项目(31671947)。
