摘要
目的观察慢性血吸虫感染患者自发性抑制性T细胞功能和T细胞亚群的改变,并探讨两者间的相互关系。方法收集本院2016年1月-2018年1月48例血吸虫感染患者的临床样本,获取患者的STs功能和CD3^+、CD4^+、CD8^+、CD4^+/CD8^+的检测结果,分析两者的相互关系。结果与正常人相比,血吸虫病患者STs功能、CD8^+数量显著升高,CD3^+和CD4^+数量以及CD4^+/CD8^+比值显著降低;与慢性血吸虫感染患者相比较,晚期血吸虫感染患者的STs功能、CD8^+数量显著升高,而CD3^+和CD4^+数量以及CD4^+/CD8^+比值显著降低,差异均有统计学意义(P<0.05)。结论血吸虫感染患者CD8^+与自发性抑制性T细胞功能分别呈正相关而CD4^+/CD8^+与自发性抑制性T细胞功能呈负相关。
Objective To observe the changes of spontaneous suppressor T cell function and T cell subsets in patients with chronic schistosomiasis infection,and explore the relationship between them.Methods The clinical samples of 48 patients with schistosomiasis infection from January 2016 to January 1818 were collected.The STs function and CD3^+,CD4^+,CD8^+,CD4^+/CD8^+test results were obtained and the relationship between them was analyzed.Results Compared with normal people,the number of STs function and CD8^+significantly increased in schistosomiasis patients,and the number of CD3^+and CD4^+and the ratio of CD4^+/CD8^+were significantly lower.While comparing with patients with chronic schistosomiasis infection,the STs function and the number of CD8^+in patients with advanced schistosomiasis infection significantly increased,while the number of CD3^+and CD4^+and the ratio of CD4^+/CD8^+were significantly lower,the differences were statistically significant(P<0.05).Conclusion CD8^+is positively correlated with spontaneous suppressor T cell function in patients with schistosomiasis infection,and CD4^+/CD8^+is negatively correlated with spontaneous suppressor T cell function.
作者
许娟
XU Juan(Third People's Hospital of Jingzhou City,Jingzhou,Hubei 434000,China)
出处
《中国卫生检验杂志》
CAS
2020年第8期989-990,996,共3页
Chinese Journal of Health Laboratory Technology
关键词
慢性血吸虫感染
自发性抑制性T细胞功能
T细胞亚群
Chronic schistosomiasis infection
Spontaneous suppressor T cell function
T cell subset
