摘要
The radical S-adenosylmethinone(SAM)superfamily is currently the largest known enzyme superfamily that consists of more than 22000 members.[1]These enzymes utilize a[4Fe-4S]cluster to bind SAM and reductively cleave it to produce a highly reactive 5'-deoxyadenosyl(dAdo)radical.This alkyl radical abstracts a hydrogen atom from the substrate to produce 5'-deoxyadenosine(dAdoH)and a substrate radical,thereby initiating remarkably diverse reactions.[1]
